N-[dimethyl(oxido)-lambda~4~-sulfanylidene]-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

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Chemical Name:N-[dimethyl(oxido)-lambda~4~-sulfanylidene]-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide
CAS No.:1268620-88-7
Molecular Formula:C₂₆H₂₄FN₅O₄S
Molecular Weight:521.572
Hs Code.:

N-[dimethyl(oxido)-lambda~4~-sulfanylidene]-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

Synonyms:N-[dimethyl(oxido)-lambda~4~-sulfanylidene]-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

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Chemical Property of N-[dimethyl(oxido)-lambda~4~-sulfanylidene]-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

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Technology Process of N-[dimethyl(oxido)-lambda~4~-sulfanylidene]-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

There total 9 articles about N-[dimethyl(oxido)-lambda~4~-sulfanylidene]-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1520-31-6
dimethylsulfoximine

: 1268620-90-1
5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxylic acid

: 1268620-88-7
N-[dimethyl(oxido)-lambda~4~-sulfanylidene]-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; at 90 ℃; for 18h; Molecular sieves 4?; Sealed vessel;

Reference yield:

: 123-30-8
4-amino-phenol

: 1268620-88-7
N-[dimethyl(oxido)-lambda~4~-sulfanylidene]-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 60 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 18 h / 92 °C / Sealed vessel; Inert atmosphere

3.1: tetrahydrofuran / 1 h / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; methanol / 5 h / 72 °C

4.2: pH 3

5.1: N-ethyl-N,N-diisopropylamine; HATU / 1,4-dioxane / 18 h / 90 °C / Molecular sieves 4?; Sealed vessel

With potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dimethyl sulfoxide;

Reference yield:

: 630125-70-1
4-((2-chloropyridin-4-yl)oxy)aniline

: 1268620-88-7
N-[dimethyl(oxido)-lambda~4~-sulfanylidene]-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 18 h / 92 °C / Sealed vessel; Inert atmosphere

2.1: tetrahydrofuran / 1 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 5 h / 72 °C

3.2: pH 3

4.1: N-ethyl-N,N-diisopropylamine; HATU / 1,4-dioxane / 18 h / 90 °C / Molecular sieves 4?; Sealed vessel

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane;