Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester

Base Information

Chemical Name:Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester
CAS No.:182699-20-3
Molecular Formula:C₁₁H₁₂F₂O₄S
Molecular Weight:278.277
Hs Code.:

Synonyms:Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester

Chemical Property:

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Technology Process of Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester

There total 3 articles about Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 182699-17-8
(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxymethyl-3-methyloxirane

: 182699-20-3
Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1246/bcsj.69.2625

Reference yield:

: 173787-23-0
(E)-2-(2,4-difluorophenyl)-2-buten-1-ol

: 182699-20-3
Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / Ti(O-iPr)4, t-butyl hydroperoxide, (-)-diethyl (2S,3S)-tartrate / CH₂Cl₂ / 48 h / -20 °C

2: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; triethylamine; In dichloromethane;
DOI:10.1246/bcsj.69.2625

Reference yield:

: tert-Butyl-[(Z)-2-(2,4-difluoro-phenyl)-but-2-enyloxy]-dimethyl-silane

: 182699-20-3
Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / Bu₄NF / tetrahydrofuran / 1 h / 0 °C

2: 96 percent / Ti(O-iPr)4, t-butyl hydroperoxide, (-)-diethyl (2S,3S)-tartrate / CH₂Cl₂ / 48 h / -20 °C

3: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1246/bcsj.69.2625