(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one

Base Information

Chemical Name:(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one
CAS No.:1042722-98-4
Molecular Formula:C₄₃H₃₃F₂NO₃
Molecular Weight:649.737
Hs Code.:

Synonyms:(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one

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Chemical Property of (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one

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Technology Process of (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one

There total 2 articles about (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.9%

: 596-43-0
bromo-triphenyl-methane

: 191330-56-0
[14C]-Sch 57871

: 1042722-98-4
(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1042723-13-6
3-{(3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(trityloxy)phenyl]azetidin-3-yl}propionyl chloride

: 352-13-6
4-flourophenylmagnesium bromide

: 1042722-98-4
(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one

Guidance literature:: 4-flourophenylmagnesium bromide; With zinc(II) chloride; In tetrahydrofuran; at 0 ℃;

3-{(3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(trityloxy)phenyl]azetidin-3-yl}propionyl chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 4 ℃; for 3h;

Reference yield: 62.5%

: 1042722-98-4
(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one

: 1042722-68-8
C₄₃H₃₅F₂NO₃

Guidance literature:: (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(trityloxy)phenyl]azetidin-2-one; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at 20 ℃; for 0.25h;

With dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane; toluene; at 20 ℃; for 0.25h;

With methanol; In tetrahydrofuran; dichloromethane; toluene;