1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

Base Information

Chemical Name:1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid
CAS No.:116855-08-4
Molecular Formula:C7H5N3O2
Molecular Weight:163.136
Hs Code.:29339900
European Community (EC) Number:874-048-3
DSSTox Substance ID:DTXSID90556420
Wikidata:Q72503540
Mol file:116855-08-4.mol

Synonyms:1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid;116855-08-4;2H-pyrazolo[3,4-b]pyridine-3-carboxylic acid;MFCD11040725;1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid;1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI);SCHEMBL1048846;DTXSID90556420;UFKAACYLUOQSFH-UHFFFAOYSA-N;BCP08141;AKOS006309689;CS-W004531;PB13318;AC-28038;DS-11116;SY021659;AM20061761;EN300-658940;A893487;J-504730;1H-Pyrazolo[3 pound not4-b]pyridin-3-carboxylicacid;1H-Pyrazolo[3 pound not4-b]pyridine-3-carboxylic acid;Z1198305721

Suppliers and Price of 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1H-Pyrazolo[3,4-b]pyridine-3-carboxylicAcid
50mg
$ 45.00

SynQuest Laboratories
1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid 98%
5 g
$ 750.00

SynQuest Laboratories
1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid 98%
1 g
$ 225.00

Matrix Scientific
1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid
1g
$ 108.00

Matrix Scientific
1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid
5g
$ 331.00

Labseeker
1H-PYRAZOLO[3,4-b]PYRIDINE-3-CARBOXYLICACID 95
100g
$ 4900.00

Labseeker
1H-PYRAZOLO[3,4-b]PYRIDINE-3-CARBOXYLICACID 95
10g
$ 1333.00

Frontier Specialty Chemicals
1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid 97%
1g
$ 693.00

Chemenu
1H-pyrazolo[3,4-b]pyridine-3-carboxylicacid 95%+
1g
$ 131.00

Chemenu
1H-pyrazolo[3,4-b]pyridine-3-carboxylicacid 95%+
5g
$ 478.00

Total 49 raw suppliers

Chemical Property of 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:265-270℃ (DEC.)
Refractive Index:1.763
Boiling Point:475.059 °C at 760 mmHg
PKA:8.83±0.20(Predicted)
Flash Point:241.107 °C
PSA：78.87000
Density:1.618 g/cm³
LogP:0.65610
Storage Temp.:2-8°C
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:163.038176411
Heavy Atom Count:12
Complexity:197

Purity/Quality:

99%, ^*data from raw suppliers

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 20/21/22
Safety Statements: 24/25-36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(NN=C2N=C1)C(=O)O
Uses 1h-Pyrazolo[3,4-B]Pyridine-3-Carboxylic Acid is a useful research chemical.

Technology Process of 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

There total 6 articles about 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 116834-96-9
3-methyl-1H-pyrazolo[3,4b]pyridine

: 116855-08-4
1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

Guidance literature:: With potassium permanganate; water; sodium hydroxide; at 80 - 90 ℃;

Reference yield:

: 55676-21-6
3-acetyl-2-chloropyridine

: 116855-08-4
1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / hydrazine hydrate / ethanol / 10 h / Heating

2: 16 percent / sodium hydroxide, potassium permanganate / H₂O / 2 h / Heating

With sodium hydroxide; potassium permanganate; hydrazine hydrate; In ethanol; water;
DOI:10.1139/v88-074

Reference yield:

: 109-09-1
2-chloropyridine

: 116855-08-4
1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -70 °C / Inert atmosphere

1.2: 3 h / -70 °C

1.3: -40 °C

2.1: chromium(VI) oxide / acetone / 3 h / -30 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 12 h / Reflux

4.1: sodium hydroxide / water / 0.17 h / 20 °C

4.2: 80 °C

4.3: pH 2

With chromium(VI) oxide; n-butyllithium; hydrazine hydrate; diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; water; acetone;