1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

Base Information

Chemical Name:1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde
CAS No.:1314734-68-3
Molecular Formula:C₁₈H₂₄BN₃O₄
Molecular Weight:357.217
Hs Code.:
Mol file:1314734-68-3.mol

Synonyms:

Suppliers and Price of 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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ACHEMBLOCK
1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde 97%
250MG
$ 1055.00

Total 4 raw suppliers

Chemical Property of 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

Chemical Property:

Boiling Point:539.5±50.0 °C(Predicted)
PKA:1.33±0.30(Predicted)
Density:1.28±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde 97% ^*data from reagent suppliers

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Technology Process of 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

There total 12 articles about 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

: 73183-34-3
bis(pinacol)diborane

: 1314734-68-3
1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1314734-59-2
1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

: 73183-34-3
bis(pinacol)diborane

: 1314734-68-3
1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 109-09-1
2-chloropyridine

: 1314734-68-3
1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 11 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane; ethylbenzene / 3 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

1.3: -40 - -10 °C / Inert atmosphere

2.1: chromium(VI) oxide / acetone / 3.25 h / -30 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / butan-1-ol / Reflux

4.1: sodium hydroxide; potassium permanganate / water / 4 h / 80 - 90 °C

5.1: sulfuric acid / 6 h / Reflux

6.1: sodium acetate; bromine / acetic acid / 120 °C / Sealed tube

7.1: water; sodium hydroxide / 3 h / 90 °C

8.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 3 h / 65 °C / Inert atmosphere

8.2: 3 h / 20 - 65 °C / Inert atmosphere

9.1: pyridinium p-toluenesulfonate / dichloromethane / Inert atmosphere; Reflux

10.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

11.1: potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

With chromium(VI) oxide; potassium permanganate; lithium aluminium tetrahydride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sulfuric acid; water; bromine; potassium acetate; sodium acetate; pyridinium p-toluenesulfonate; hydrazine hydrate; 1,1'-carbonyldiimidazole; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; ethylbenzene; water; acetic acid; N,N-dimethyl-formamide; acetone; butan-1-ol;