dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate

Base Information

• Chemical Name: dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate
• CAS No.: 169616-09-5
• Molecular Formula: C₂₁H₂₇NO₈
• Molecular Weight: 421.447
• Mol file: 169616-09-5.mol

Synonyms:dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate

Chemical Property of dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate

There total 6 articles about dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methoxy-ethyl p-toluenesulfonyloxy ester (17178-10-8,58320-73-3) + dimethyl-1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate (148528-45-4) → dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate (169616-09-5)

Guidance literature:

With potassium carbonate; In acetonitrile; for 15h; Reflux;

DOI:10.1007/s00706-008-0057-7

Reference yield: 77.0%

2-methoxyethyl methanesulfonate (16427-44-4) + dimethyl-1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate (148528-45-4) → dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate (169616-09-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 8h;

DOI:10.1055/s-1995-3993

Reference yield:

dimethyl iminodiacetate (6096-81-7) → dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate (169616-09-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / NaHCO₃ / dimethylformamide / 14 h / 40 °C

2: 58 percent / NaOMe / methanol / 18 h / Heating

3: 77 percent / K₂CO₃ / dimethylformamide / 8 h / 130 °C

With sodium methylate; sodium hydrogencarbonate; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1055/s-1995-3993

upstream raw materials:

2-methoxyethyl methanesulfonate

dimethyl-1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate

dimethyl iminodiacetate

dimethyl 3,4-dihydroxy-1H-pyrrole-2,5-dicarboxylate