2-Methoxyethyl methanesulfonate

Base Information

• Chemical Name: 2-Methoxyethyl methanesulfonate
• CAS No.: 16427-44-4
• Molecular Formula: C4H10 O4 S
• Molecular Weight: 154.187
• Hs Code.: 2909499000
• European Community (EC) Number: 605-354-5,627-246-7
• DSSTox Substance ID: DTXSID90167737
• Nikkaji Number: J2.173.183H
• Wikidata: Q72489832
• Mol file: 16427-44-4.mol

Synonyms:2-Methoxyethyl methanesulfonate;16427-44-4;Methanesulfonic Acid 2-Methoxyethyl Ester;175172-61-9;Ethanol, 2-methoxy-, methanesulfonate;Ethanol, 2-methoxy-, 1-methanesulfonate;2-Methoxymethyl Methansulfonate;2-Methoxyethanol methanesulfonate;MFCD02656401;Poly(oxy-1,2-ethanediyl), alpha-(methylsulfonyl)-omega-methoxy-;MFCD03100948;2-methoxyethylmethanesulfonate;2-methoxyethyl mesylate;SCHEMBL263556;2-methoxyethyl methane sulfonate;DTXSID90167737;AM778;AKOS015908692;CS-W018040;DS-4179;Methanesulfonic Acid2-Methoxyethyl Ester;SY055164;Methanesulfonic acid 2-methoxy-ethyl ester;FT-0659197;M1446;F19933;EN300-7072323;Ethylene Glycol Monomethyl Ether Methanesulfonate;A810549

Chemical Property of 2-Methoxyethyl methanesulfonate

Chemical Property:

• Vapor Pressure: 0.0215mmHg at 25°C
• Refractive Index: 1.425
• Boiling Point: 126 °C / 12mmHg
• Flash Point: 110.4°C
• PSA: 60.98000
• Density: 1.25
• LogP: 0.68980
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 154.02997997
• Heavy Atom Count: 9
• Complexity: 142

Purity/Quality:

98% ^*data from raw suppliers

2-MethoxymethylMethansulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOS(=O)(=O)C
• Uses: 2-Methoxymethyl Methansulfonate is used in the ring-opening polymerization of lactide. Also used in the synthesis of acetylcholine receptor ligands.

Technology Process of 2-Methoxyethyl methanesulfonate

There total 3 articles about 2-Methoxyethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxy-ethanol (109-86-4,95507-80-5) + methanesulfonyl chloride (124-63-0) → 2-methoxyethyl methanesulfonate (16427-44-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃;

Reference yield: 98.0%

1-methyl-1H-imidazole (616-47-7) + 2-methoxy-ethanol (109-86-4,95507-80-5) + methanesulfonyl chloride (124-63-0) → 2-methoxyethyl methanesulfonate (16427-44-4) + 1-methylimidazolium chloride (35487-17-3)

Guidance literature:

In dichloromethane; at 10 - 20 ℃; for 4h;

Reference yield:

→ 2-methoxyethyl methanesulfonate (16427-44-4)

Guidance literature:

upstream raw materials:

2-methoxy-ethanol

methanesulfonyl chloride

1-methyl-1H-imidazole

Downstream raw materials:

fluoro-1, methoxy-2 ethane

2-methoxy-ethanol

N,N-Bis(2-(2-methoxyethoxy)ethyl)benzene amine

3'-O-methoxyethyladenosine

Refernces

• 1、 Zhao, Ying,Wang, Jianying,Jiang, Haichao,Hu, Yongqi. "Study on the thermodynamic properties of ether-functionalized imidazolium-based ionic liquids". . p. 314 - 318. Retrieved 2014.
• 2、 Gronert, Scott,Streitwieser, Andrew. "Carbon Acidity. 74. The Effects of Hetero-Substituted Pendant Groups on Carbanion Reactivity. Solvent-Separated-Contact Ion Pair Equilibria and Relative pKLi/THF's for 9-Substituted Fluorenyllithiums in Tetrahydrofuran. The Importance of Internal Chelation". . p. 2836 - 2842. Retrieved 1988.
• 3、 -. "Pyridazinone compound, preparation method thereof, pharmaceutical composition and its use". Paragraph 0248; 0250-0251; 0261-0262. . Retrieved 2018/04/02.
• 4、 Lozano-Torres, Beatriz,El Sayed, Sameh,Costero, Ana M.,Gil, Salvador,Parra, Margarita,Martínez-Má?ez, Ramón,Sancenón, Félix. "Selective and sensitive chromogenic detection of trivalent metal cations in water". supporting information. p. 498 - 500. Retrieved 2016/04/26.