(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide

Base Information

Chemical Name:(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide
CAS No.:1296137-06-8
Molecular Formula:C₃₂H₄₁N₃O₄
Molecular Weight:531.695
Hs Code.:

Synonyms:(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide

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Chemical Property of (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide

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Technology Process of (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide

There total 12 articles about (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6482-32-2
2-(hydroxymethyl)butane-1,4-diol

: 1296137-06-8
(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C

2.1: pyridine / dichloromethane / 5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide

3.2: 10 h / 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C

With pyridine; hydrogenchloride; water; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.01.034

Reference yield:

: C₃₅H₄₅N₃O₄

: 1296137-06-8
(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide

Guidance literature:: C₃₅H₄₅N₃O₄; With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1016/j.ejmech.2011.01.034

Reference yield:

: 1041756-57-3
[4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone

: 1296137-06-8
(E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide

2.2: 10 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.01.034