6-(N-3-butenylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine

Base Information

Chemical Name:6-(N-3-butenylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine
CAS No.:220545-62-0
Molecular Formula:C₂₃H₃₀N₄O₄
Molecular Weight:426.516
Hs Code.:

Synonyms:6-(N-3-butenylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine

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Chemical Property of 6-(N-3-butenylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine

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Technology Process of 6-(N-3-butenylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine

There total 5 articles about 6-(N-3-butenylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 220545-83-5
6-(N-3-butynylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine

: 220545-62-0
6-(N-3-butenylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine

Guidance literature:: With hydrogen; Pd-BaSO₄; In pyridine; for 5h; under 760 Torr; Ambient temperature;
DOI:10.1016/S0040-4020(98)01060-6

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 220545-62-0
6-(N-3-butenylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Et₃N, 3.) NaBH₄ / 1.) MeOH, room temperature, 1 h, 2.) room temperature, 1 h, 3.) 0 deg C, 1 h

2: 98 percent / Et₃N / ethanol / 6 h / Heating

3: 80 percent / methanol / 3.5 h / Heating

4: 83 percent / DMAP / toluene / 48 h / Heating

5: 94 percent / H₂ / Pd/BaSO₄ / pyridine / 5 h / 760 Torr / Ambient temperature

With dmap; sodium tetrahydroborate; hydrogen; triethylamine; Pd-BaSO₄; In pyridine; methanol; ethanol; toluene;
DOI:10.1016/S0040-4020(98)01060-6

Reference yield:

: 146980-79-2
N-(4-methoxybenzyl)-4-amino-1-butyne

: 220545-62-0
6-(N-3-butenylamino-N-4-methoxybenzyl)-5-formyl-4-methoxy-2-pivaloylaminopyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Et₃N / ethanol / 6 h / Heating

2: 80 percent / methanol / 3.5 h / Heating

3: 83 percent / DMAP / toluene / 48 h / Heating

4: 94 percent / H₂ / Pd/BaSO₄ / pyridine / 5 h / 760 Torr / Ambient temperature

With dmap; hydrogen; triethylamine; Pd-BaSO₄; In pyridine; methanol; ethanol; toluene;
DOI:10.1016/S0040-4020(98)01060-6