Pyridine, 2-fluoro-6-methoxy- (9CI)

Base Information

• Chemical Name: Pyridine, 2-fluoro-6-methoxy- (9CI)
• CAS No.: 116241-61-3
• Molecular Formula: C6H6FNO
• Molecular Weight: 127.12
• Hs Code.: 2933399090
• Mol file: 116241-61-3.mol

Synonyms:2-Fluoro-6-methoxypyridine;

Chemical Property of Pyridine, 2-fluoro-6-methoxy- (9CI)

Chemical Property:

• Vapor Pressure: 7.35mmHg at 25°C
• Refractive Index: 1.471
• Boiling Point: 141.3 °C at 760 mmHg
• PKA: -2.26±0.10(Predicted)
• Flash Point: 39.3 °C
• PSA: 22.12000
• Density: 1.146 g/cm³
• LogP: 1.22930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-6-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 2-fluoro-6-methoxy- (9CI)

There total 4 articles about Pyridine, 2-fluoro-6-methoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methanol (67-56-1) + 2,6-difluoro pyridine (1513-65-1) → 2-(methoxy)-6-fluoropyridine (116241-61-3)

Guidance literature:

With sodium hydroxide;

Reference yield: 57.0%

2-methoxypyridine (1628-89-3) → 2-(methoxy)-6-fluoropyridine (116241-61-3)

Guidance literature:

With silver(II) fluoride; In acetonitrile; at 25 ℃; for 0.25h; regioselective reaction; Inert atmosphere; Glovebox;

Reference yield:

2,6-difluoro pyridine (1513-65-1) + sodium methylate (124-41-4) → 2-(methoxy)-6-fluoropyridine (116241-61-3)

Guidance literature:

In tetrahydrofuran; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.ica.2017.06.063

upstream raw materials:

N-Fluoro-2-methoxypyridinium tetrafluoroborate

2-methoxypyridine

2,6-difluoro pyridine

sodium methylate

Refernces

• 1、 Siek, Sopheavy,Burks, Dalton B.,Gerlach, Deidra L.,Liang, Guangchao,Tesh, Jamie M.,Thompson, Courtney R.,Qu, Fengrui,Shankwitz, Jennifer E.,Vasquez, Robert M.,Chambers, Nicole,Szulczewski, Gregory J.,Grotjahn, Douglas B.,Webster, Charles Edwin,Papish, Elizabeth T.. "Iridium and ruthenium complexes of N-heterocyclic carbene- and pyridinol-derived chelates as catalysts for aqueous carbon dioxide hydrogenation and formic acid dehydrogenation: The role of the alkali metal". . p. 1091 - 1106. Retrieved 2017.
• 2、 -. "C-H FLUORINATION OF HETEROCYCLES WITH SILVER (II) FLUORIDE". Paragraph 00153. . Retrieved 2015/02/19.