lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate

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Chemical Name:lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate
CAS No.:1393901-60-4
Molecular Formula:C₂₉H₃₂F₃N₆O₄*Li
Molecular Weight:592.547
Hs Code.:

Synonyms:lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate

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Chemical Property of lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate

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Technology Process of lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate

There total 12 articles about lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1393901-60-4
lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 85 - 90 °C

2.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide; ethanol / 24 h / 20 °C

3.1: zinc(II) chloride / 1,2-dichloro-ethane; tert-butyl alcohol / 1 h / 0 °C / Inert atmosphere

3.2: 24.5 h / 0 - 20 °C

4.1: triethylamine / copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; sodium carbonate; triethylamine; lithium chloride; zinc(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 170011-57-1
tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate

: 1393901-60-4
lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc(II) chloride / 1,2-dichloro-ethane; tert-butyl alcohol / 1 h / 0 °C / Inert atmosphere

1.2: 24.5 h / 0 - 20 °C

2.1: triethylamine / copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; microwave irradiation

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; triethylamine; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 387827-33-0
tert-butyl 4-(4-nitrophenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1393901-60-4
lithium 2-(4-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrimidin-5-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide; ethanol / 24 h / 20 °C

2.1: zinc(II) chloride / 1,2-dichloro-ethane; tert-butyl alcohol / 1 h / 0 °C / Inert atmosphere

2.2: 24.5 h / 0 - 20 °C

3.1: triethylamine / copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; triethylamine; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; ethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;