4-Isoxazolecarboxylicacid,3-(4-methoxyphenyl)-5-phenyl-,methylester(9CI)

Base Information

• Chemical Name: 4-Isoxazolecarboxylicacid,3-(4-methoxyphenyl)-5-phenyl-,methylester(9CI)
• CAS No.: 115665-24-2
• Molecular Formula: C18H15 N O4
• Molecular Weight: 309.32
• Mol file: 115665-24-2.mol

Synonyms:4-Isoxazolecarboxylicacid,3-(4-methoxyphenyl)-5-phenyl-,methylester(9CI)

Chemical Property of 4-Isoxazolecarboxylicacid,3-(4-methoxyphenyl)-5-phenyl-,methylester(9CI)

Chemical Property:

• PSA: 61.56000
• LogP: 3.80380

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Isoxazolecarboxylicacid,3-(4-methoxyphenyl)-5-phenyl-,methylester(9CI)

There total 3 articles about 4-Isoxazolecarboxylicacid,3-(4-methoxyphenyl)-5-phenyl-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

phenylpropynoic acid methyl ester (4891-38-7) + 4-methoxybenzonitrile oxide (15500-73-9) → methyl 3-(4-methoxyphenyl)-5-phenylisoxazole-4-carboxylate (115665-24-2)

Guidance literature:

for 48h; Ambient temperature;

Reference yield:

phenylpropynoic acid methyl ester (4891-38-7) + N-hydroxy-4-methoxy-benzenecarboximidoyl chloride (38435-51-7) → methyl 3-(4-methoxyphenyl)-4-phenylisoxazole-5-carboxylate (1092557-19-1) + methyl 3-(4-methoxyphenyl)-5-phenylisoxazole-4-carboxylate (115665-24-2)

Guidance literature:

With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 10h; regioselective reaction;

DOI:10.1002/anie.200801920

Reference yield:

N-chloro-4-methoxybenzamide (33349-24-5) → methyl 3-(4-methoxyphenyl)-5-phenylisoxazole-4-carboxylate (115665-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (C₂H₅)3N / diethyl ether / 0.5 h / -5 - 0 °C

2: 72 percent / 48 h / Ambient temperature

With triethylamine; In diethyl ether;

upstream raw materials:

phenylpropynoic acid methyl ester

4-methoxybenzonitrile oxide

N-chloro-4-methoxybenzamide

N-hydroxy-4-methoxy-benzenecarboximidoyl chloride