1-Ethoxy-9H-carbazole

Base Information

• Chemical Name: 1-Ethoxy-9H-carbazole
• CAS No.: 115663-18-8
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.263
• DSSTox Substance ID: DTXSID20553902
• Wikidata: Q82434624
• Mol file: 115663-18-8.mol

Synonyms:1-Ethoxy-9H-carbazole;115663-18-8;9H-Carbazole,1-ethoxy-(9CI);SCHEMBL5018077;DTXSID20553902

Chemical Property of 1-Ethoxy-9H-carbazole

Chemical Property:

• PSA: 25.02000
• LogP: 3.71980
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 211.099714038
• Heavy Atom Count: 16
• Complexity: 243

Purity/Quality:

1-ethoxy-9H-Carbazole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC2=C1NC3=CC=CC=C23

Technology Process of 1-Ethoxy-9H-carbazole

There total 8 articles about 1-Ethoxy-9H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

ethanol (64-17-5) + 1-indol-2-ylbutane-1,4-dione (103763-44-6) → 1-ethoxy-9H-carbazole (115663-18-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/S0040-4039(00)98941-X

Reference yield:

1-ethoxy-9-tetrahydro-2H-2-pyranyl-9H-carbazole → 1-ethoxy-9H-carbazole (115663-18-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; for 3h; Heating / reflux;

Reference yield:

4,5-dihydro-3-indol-2-ylcarbonylfuran-2-one (69963-25-3) → 1-ethoxy-9H-carbazole (115663-18-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / water / aq. NaOH / dioxane / 17 h / 110 °C

2: 70 percent / PCC / CH₂Cl₂ / 2 h / Ambient temperature

3: 46 percent / sat. HCl / 17 h / Ambient temperature

With hydrogenchloride; water; pyridinium chlorochromate; sodium hydroxide; In 1,4-dioxane; dichloromethane;

upstream raw materials:

1-hydroxycarbazole

ethyl iodide

8-ethoxy-1,2,3,4-tetrahydro-carbazole

ethanol