Technology Process of (2R)-2-(2'-(benzyloxy)-4'-bromo-6'-methoxyphenoxy)-propanal
There total 7 articles about (2R)-2-(2'-(benzyloxy)-4'-bromo-6'-methoxyphenoxy)-propanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
hexane; dichloromethane;
at -78 ℃;
for 0.2h;
Inert atmosphere;
DOI:10.1021/jo3015006
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ammonium cerium (IV) nitrate; bromine; silica gel / tetrachloromethane / 6 h / 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 73 h / 0 - 20 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere
4.2: 96 h / 0 - 20 °C / Inert atmosphere
5.1: hydrogenchloride / methanol; water / 18 h / 20 °C / Inert atmosphere
6.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3.17 h / 0 - 20 °C / Inert atmosphere
7.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.2 h / -78 °C / Inert atmosphere
With
hydrogenchloride; ammonium cerium (IV) nitrate; di-isopropyl azodicarboxylate; bromine; silica gel; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; water; N,N-dimethyl-formamide;
3.1: |Baeyer-Villiger Ketone Oxidation / 6.1: |Mitsunobu Displacement;
DOI:10.1021/jo3015006
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 73 h / 0 - 20 °C / Inert atmosphere
2.2: 1 h / 20 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere
3.2: 96 h / 0 - 20 °C / Inert atmosphere
4.1: hydrogenchloride / methanol; water / 18 h / 20 °C / Inert atmosphere
5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3.17 h / 0 - 20 °C / Inert atmosphere
6.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.2 h / -78 °C / Inert atmosphere
With
hydrogenchloride; di-isopropyl azodicarboxylate; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
2.1: |Baeyer-Villiger Ketone Oxidation / 5.1: |Mitsunobu Displacement;
DOI:10.1021/jo3015006
