Technology Process of 5-bromo-3-methoxy-2-(methoxymethoxy)phenol
There total 4 articles about 5-bromo-3-methoxy-2-(methoxymethoxy)phenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-3-methoxy-2-(methoxymethyloxy)benzaldehyde;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 73h;
Inert atmosphere;
With
methanol; potassium hydroxide;
at 20 ℃;
for 1h;
DOI:10.1055/s-0036-1588939
- Guidance literature:
-
5-bromo-3-methoxy-2-[(triisopropylsilyl)oxy]benzaldehyde;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 73h;
Inert atmosphere;
chloromethyl methyl ether;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 0 ℃;
DOI:10.1055/s-0036-1588939
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid; sodium acetate; bromine / 0.5 h / 0 - 20 °C
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 73 h / 0 - 20 °C / Inert atmosphere
3.2: 1 h / 20 °C
With
bromine; sodium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
3.1: |Dakin Phenol Oxidation / 3.2: |Dakin Phenol Oxidation;
DOI:10.1055/s-0036-1588939
