2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-aminoquinolin-4-yl)methyl)phenyl)propanenitrile

Base Information

Chemical Name:2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-aminoquinolin-4-yl)methyl)phenyl)propanenitrile
CAS No.:1201645-63-7
Molecular Formula:C₂₅H₂₉N₅
Molecular Weight:399.539
Hs Code.:

Synonyms:2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-aminoquinolin-4-yl)methyl)phenyl)propanenitrile

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Chemical Property of 2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-aminoquinolin-4-yl)methyl)phenyl)propanenitrile

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Technology Process of 2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-aminoquinolin-4-yl)methyl)phenyl)propanenitrile

There total 13 articles about 2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-aminoquinolin-4-yl)methyl)phenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1201645-61-5
2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile

: 1201645-63-7
2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-aminoquinolin-4-yl)methyl)phenyl)propanenitrile

Guidance literature:: With hydrogen; nickel; In tetrahydrofuran; at 25 ℃; under 760.051 Torr;

Reference yield:

: 4-(1-cyano-1-methylethyl)benzoic acid chloride

: 1201645-63-7
2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-aminoquinolin-4-yl)methyl)phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

1.2: 25 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

6.1: hydrogenchloride / acetone / 24 h

7.1: hydrogenchloride / water / 24 h

8.1: potassium acetate / ethanol / 5 h / Reflux

9.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 15 h / 14 °C

10.1: hydrogen / nickel / tetrahydrofuran / 25 °C / 760.05 Torr

With hydrogenchloride; triethylsilane; aluminum (III) chloride; sodium tetrahydroborate; hydrogen; potassium acetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; ozone; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 129488-74-0
4-(1-cyano-1-methylethyl)benzoic acid

: 1201645-63-7
2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-aminoquinolin-4-yl)methyl)phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

2.2: 25 °C

3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

6.1: hydrogenchloride / acetone / 24 h

7.1: hydrogenchloride / water / 24 h

8.1: potassium acetate / ethanol / 5 h / Reflux

9.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 15 h / 14 °C

10.1: hydrogen / nickel / tetrahydrofuran / 25 °C / 760.05 Torr

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; oxalyl dichloride; hydrogen; potassium acetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; ozone; N,N-dimethyl-formamide; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;