(R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)-N-methyl-(S)-propanamide

Base Information

Chemical Name:(R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)-N-methyl-(S)-propanamide
CAS No.:1344706-36-0
Molecular Formula:C₂₄H₂₀F₃N₅O₅
Molecular Weight:515.449
Hs Code.:

Synonyms:(R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)-N-methyl-(S)-propanamide

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Chemical Property of (R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)-N-methyl-(S)-propanamide

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Technology Process of (R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)-N-methyl-(S)-propanamide

There total 8 articles about (R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)-N-methyl-(S)-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.2%

: 1344708-41-3,1344708-42-4,1344708-43-5
(R/S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid

: 61275-22-7
L-alanine-N-methylamide hydrochloride

: 1344706-36-0
(R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)-N-methyl-(S)-propanamide

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1344706-36-0
(R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)-N-methyl-(S)-propanamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

3: Jones reagent / acetone / 20 °C

4: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile

6: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

7: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

With 4-methyl-morpholine; pyridine; N-chloro-succinimide; Jones reagent; trifluoro-[1,3,5]triazine; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 934-16-7
phenylhydroxamoyl chloride

: 1344706-36-0
(R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)-N-methyl-(S)-propanamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

2: Jones reagent / acetone / 20 °C

3: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile

5: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

6: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

With 4-methyl-morpholine; pyridine; Jones reagent; trifluoro-[1,3,5]triazine; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;