61275-22-7

Basic information

• Product Name: H-ALA-NHME HCL
• Synonyms: H-ALA-NHME HCL;L-ALANINE METHYLAMIDE HYDROCHLORIDE;L-ALANINE N-METHYLAMIDE HYDROCHLORIDE;ALANINE-NHME HCL;N~1~-methyl-L-alaninamide hydrochloride;propanamide, 2-amino-N-methyl-, (2S)-;H-Ala-NHMe;(S)-2-AMino-N-MethylpropanaMide hydrochloride
• CAS NO: 61275-22-7
• Molecular Formula: C₄H₁₀N₂O*ClH
• Molecular Weight: 138.6
• Mol File: 61275-22-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 218-220 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
• Boiling Point: 257°C at 760 mmHg
• Flash Point: 109.2°C
• Appearance: /
• Density: 0.976g/cm³
• Vapor Pressure: 0.0149mmHg at 25°C
• Refractive Index: 1.442
• Storage Temp.: Store at 0-5°C
• CAS DataBase Reference: H-ALA-NHME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-ALA-NHME HCL(61275-22-7)
• EPA Substance Registry System: H-ALA-NHME HCL(61275-22-7)

Safety Data

• Hazardous Substances Data: 61275-22-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder or solid

Uses

H-Ala-NHMe HCl

InChI:InChI=1/C4H10N2O/c1-3(5)4(7)6-2/h3H,5H2,1-2H3,(H,6,7)/t3-/m0/s1

Upstream product

• 84851-00-3 tert-butyl N-[(1S)-1-(methylcarbamoyl)ethyl]carbamate 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 74-89-5 methylamine 
• 1115-59-9 (S)-alanine ethyl ester hydrochloride 

Downstream Products

• 942203-08-9 (2S,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[1'-(methylcarbamoyl)ethyl]carbamoylazetidine 
• 942203-07-8 C₁₇H₂₃N₃O₄ 
• 1344706-36-0 (R/S)-2-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)-N-methyl-(S)-propanamide 
• 1161500-70-4 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-N-((S)-1-methylcarbamoylethyl)benzamide 
• 1228316-05-9 C₂₇H₄₈N₆O₃ 
• 143457-42-5 N-{D,L-2-(hydroxyaminocarbonyl)methyl-4-methylpentanoyl}-L-3-(2'-naphthyl)alanyl-L-alanine Methylamide 
• 855259-08-4 Trt-(3-Me-Azy)-Ala-NHMe 
• 660391-70-8 Fmoc-phenylselenocysteinylalanine-N-methyl amide 
• 191409-11-7 (6S,7R,10S)-7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexadeca-1⁽¹⁵⁾,12⁽¹⁶⁾,13-triene-6,10-dicarboxylic acid 6-(benzyloxy-amide) 10-[((S)-1-methylcarbamoyl-ethyl)-amide] 
• 19701-83-8 N-acetyl-N'-methyl-L-alanylamide 

Relevant articles and documents

INHIBITORS OF RAF KINASES

Provided herein are inhibitors of receptor tyrosine kinase effector, RAF, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Mechanistic Studies on the Organocatalytic α-Chlorination of Aldehydes: The Role and Nature of Off-Cycle Intermediates

Herein we report the isolation and characterization of aminal intermediates in the organocatalytic α-chlorination of aldehydes. These species are stable covalent ternary adducts of the substrate, the catalyst and the chlorinating reagent. NMR-assisted kinetic studies and isotopic labeling experiments with the isolated intermediate did not support its involvement in downstream stereoselective processes as proposed by Blackmond. By tuning the reactivity of the chlorinating reagent, we were able to suppress the accumulation of rate-limiting off-cycle intermediates. As a result, an efficient and highly enantioselective catalytic system with a broad functional group tolerance was developed.

The preparation of (2r,5s)-2-t-butyl-3,5-dimethylimidazolidin-4-one

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