(S)-2-Amino-N-methylpropanamide hydrochloride

Base Information

• Chemical Name: (S)-2-Amino-N-methylpropanamide hydrochloride
• CAS No.: 61275-22-7
• Molecular Formula: C4H10 N2 O . Cl H
• Molecular Weight: 138.597
• Hs Code.: 2924199090
• European Community (EC) Number: 855-472-8
• DSSTox Substance ID: DTXSID90595071
• Mol file: 61275-22-7.mol

Synonyms:61275-22-7;(S)-2-Amino-N-methylpropanamide hydrochloride;H-ALA-NHME HCL;H-Ala-NHMe.HCl;H-Ala-nhme hydrochloride;(2S)-2-amino-N-methylpropanamide;hydrochloride;N-methyl-L-alaninamide hydrochloride;MFCD00237739;L-Alanine methylamide hydrochloride;L-Alanine methylamide HCl;N~1~-methylalaninamide hydrochloride;SCHEMBL555916;DTXSID90595071;Propanamide, 2-amino-N-methyl-, monohydrochloride, (2S)-;N-methyl-alaninamide hydrochloride;UHWFDFLWTAIHRE-DFWYDOINSA-N;(S)-2-amino-N-methylpropanamide-HCl;AKOS005257140;AKOS015998957;(S)-N-methyl-alaninamide hydrochloride;FD21069;N~1~-methyl-L-alaninamide hydrochloride;DS-16853;DB-300098;CS-0169314;EN300-220970;(2S)-2-Amino-N-Methylpropanamide Hydrochloride;A868763;N-Methyl-L-alaninamide--hydrogen chloride (1/1);Z1449756238;Propanamide,2-amino-N-methyl-,hydrochloride(1:1),(2S)-

Chemical Property of (S)-2-Amino-N-methylpropanamide hydrochloride

Chemical Property:

• Vapor Pressure: 0.0149mmHg at 25°C
• Melting Point: 218-220 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
• Boiling Point: 257°C at 760 mmHg
• Flash Point: 109.2°C
• PSA: 55.12000
• Density: 0.976g/cm³
• LogP: 0.97280
• Storage Temp.: Store at 0-5°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 138.0559907
• Heavy Atom Count: 8
• Complexity: 72.1

Purity/Quality:

97% ^*data from raw suppliers

H-Ala-NHMe HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)NC)N.Cl
• Isomeric SMILES: C[C@@H](C(=O)NC)N.Cl
• Uses: H-Ala-NHMe HCl

Technology Process of (S)-2-Amino-N-methylpropanamide hydrochloride

There total 4 articles about (S)-2-Amino-N-methylpropanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl N-[(1S)-1-(methylcarbamoyl)ethyl]carbamate (84851-00-3) → L-alanine-N-methylamide hydrochloride (61275-22-7)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1h;

DOI:10.1021/ol048771l

Reference yield: 95.0%

L-alanine methyl ester hydrochloride (2491-20-5) + methylamine (74-89-5) → L-alanine-N-methylamide hydrochloride (61275-22-7)

Guidance literature:

In ethanol; at 22 ℃; for 12h;

DOI:10.1002/anie.201806261

Reference yield:

(S)-alanine ethyl ester hydrochloride (1115-59-9) → L-alanine-N-methylamide hydrochloride (61275-22-7)

Guidance literature:

(S)-alanine ethyl ester hydrochloride; With methylamine; In ethanol; for 97h;

With sodium hydrogencarbonate; potassium carbonate; In water;

With hydrogenchloride; In diethyl ether; for 0.166667h;

DOI:10.1016/j.tet.2011.04.009

upstream raw materials:

tert-butyl N-[(1S)-1-(methylcarbamoyl)ethyl]carbamate

(S)-alanine ethyl ester hydrochloride

L-alanine methyl ester hydrochloride

methylamine

Downstream raw materials:

Fmoc-phenylselenocysteinylalanine-N-methyl amide

C₂₇H₄₈N₆O₃

C₁₇H₂₃N₃O₄

(2S,1'S)-2-benzyl-1-benzyloxycarbonyl-2-[1'-(methylcarbamoyl)ethyl]carbamoylazetidine