(S)-benzyl 2-(tert-butoxycarbonylamino)-4-hydroxy-3 ,3-dimethylbutanoate

Base Information

Chemical Name:(S)-benzyl 2-(tert-butoxycarbonylamino)-4-hydroxy-3 ,3-dimethylbutanoate
CAS No.:858034-62-5
Molecular Formula:C₁₈H₂₇NO₅
Molecular Weight:337.416
Hs Code.:

Synonyms:(S)-benzyl 2-(tert-butoxycarbonylamino)-4-hydroxy-3 ,3-dimethylbutanoate

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Chemical Property of (S)-benzyl 2-(tert-butoxycarbonylamino)-4-hydroxy-3 ,3-dimethylbutanoate

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Technology Process of (S)-benzyl 2-(tert-butoxycarbonylamino)-4-hydroxy-3 ,3-dimethylbutanoate

There total 9 articles about (S)-benzyl 2-(tert-butoxycarbonylamino)-4-hydroxy-3 ,3-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 157717-56-1
tert-butyl (S)-(4,4-dimethyl-2-oxotetrahydrofuran-3-yl)carbamate

: 858034-62-5
(S)-benzyl 2-(tert-butoxycarbonylamino)-4-hydroxy-3 ,3-dimethylbutanoate

Guidance literature:: benzyl bromide; tert-butyl (S)-(4,4-dimethyl-2-oxotetrahydrofuran-3-yl)carbamate; With water; potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

benzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: C₁₁H₂₁NO₅

: 100-39-0
benzyl bromide

: 858034-62-5
(S)-benzyl 2-(tert-butoxycarbonylamino)-4-hydroxy-3 ,3-dimethylbutanoate

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 599-04-2
(R)-Pantolacton

: 858034-62-5
(S)-benzyl 2-(tert-butoxycarbonylamino)-4-hydroxy-3 ,3-dimethylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 1.5 h / -78 - 20 °C

2.1: tetra-n-butylammonium azide / dichloromethane / 16 h / 20 °C

3.1: hydrogen; palladium 10% on activated carbon / methanol / 16 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C

4.1: potassium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

4.2: 16 h / 20 °C

With pyridine; palladium 10% on activated carbon; tetra-n-butylammonium azide; water; hydrogen; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;