N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(z)-2-butenamide

Base Information

Chemical Name:N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(z)-2-butenamide
CAS No.:214485-04-8
Molecular Formula:C₂₂H₁₉ClFN₅O
Molecular Weight:423.877
Hs Code.:

Synonyms:N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(z)-2-butenamide

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Chemical Property of N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(z)-2-butenamide

Chemical Property:

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Technology Process of N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(z)-2-butenamide

There total 8 articles about N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(z)-2-butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51544-74-2
4-bromocrotonic acid chloride

: 124-40-3
dimethyl amine

: 214485-08-2
6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-quinoline-3-carbonitrile

: 214485-04-8
N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(z)-2-butenamide

Guidance literature:: 4-bromocrotonic acid chloride; 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-quinoline-3-carbonitrile; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 1h;

dimethyl amine; In tetrahydrofuran; at -78 - 25 ℃; for 3h;

Reference yield:

: 214485-50-4
N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-2-butynamide

: 5244-34-8
2,2'-ethane-1,2-diylbissulfanyl-bis-ethanol

: 214485-04-8
N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(z)-2-butenamide

Guidance literature:: In methanol; ethyl acetate;

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 214485-04-8
N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(z)-2-butenamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 3.5 h / Heating / reflux

2.1: ethanol; tin(ll) chloride / water / 1.5 h / Heating / reflux

2.2: 2 h

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

3.2: 3 h / -78 - 25 °C

With ethanol; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; water;