1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Base Information

Chemical Name:1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine
CAS No.:1402608-50-7
Molecular Formula:C₂₅H₂₆N₄O
Molecular Weight:398.508
Hs Code.:

Synonyms:1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

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Chemical Property of 1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

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Technology Process of 1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

There total 4 articles about 1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1402609-41-9
tert-butyl {1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]-pyridazin-2-yl)phenyl]cyclobutyl}carbamate

: 1402608-50-7
1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Guidance literature:: tert-butyl {1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]-pyridazin-2-yl)phenyl]cyclobutyl}carbamate; With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; at 20 ℃;

With sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; pH=> 7; Cooling with ice;

Reference yield:

: 76593-36-7
3-amino-6-chloro-4,5-dimethylpyridazine

: 1402608-50-7
1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 1 h / 30 °C / Microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine / propyl cyanide / 3 h / 120 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 °C

3.2: pH > 7 / Cooling with ice

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; propyl cyanide; dichloromethane;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1402608-50-7
1-[4-(6-methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / propyl cyanide / 3 h / 120 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 °C

3.2: pH > 7 / Cooling with ice

With hydrogenchloride; pyridinium hydrobromide perbromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; propyl cyanide; dichloromethane;