(2R,3S)-methyl 3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxylate

Base Information

Chemical Name:(2R,3S)-methyl 3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxylate
CAS No.:1267588-03-3
Molecular Formula:C₁₈H₁₆O₄
Molecular Weight:296.323
Hs Code.:

Synonyms:(2R,3S)-methyl 3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxylate

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Chemical Property of (2R,3S)-methyl 3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxylate

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Technology Process of (2R,3S)-methyl 3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxylate

There total 16 articles about (2R,3S)-methyl 3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 67-56-1
methanol

: 126861-88-9
(E)-2-(2-(3-oxo-3-phenylprop-1-en-1-yl)phenoxy)acetic acid

: 1267588-03-3
(2R,3S)-methyl 3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxylate

Guidance literature:: (E)-2-(2-(3-oxo-3-phenylprop-1-en-1-yl)phenoxy)acetic acid; With pivaloyl chloride; levamisole hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 0.583333h;

methanol; In dichloromethane; at 20 - 25 ℃; for 1h; stereospecific reaction;
DOI:10.1021/ja109975c

Reference yield: 64.0%

: 67-56-1
methanol

: C₁₇H₁₄O₄

: 1267588-03-3
(2R,3S)-methyl 3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxylate

Guidance literature:: C₁₇H₁₄O₄; With (S,R(P))-2-phenyl-2,3-dihydroimidazo[1,2-a]pyrindinyl-pentaphenylcyclopentadienyliron; pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 ℃; for 5h;

methanol; at 20 ℃; stereoselective reaction;
DOI:10.1002/cjoc.201400186

Reference yield:

: 20913-05-7,859-65-4
(Benzoylmethylene)triphenylphosphorane

: 1267588-03-3
(2R,3S)-methyl 3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloroform / Reflux; Inert atmosphere

2.1: pivaloyl chloride; levamisole hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.58 h / 0 - 25 °C

2.2: 1 h / 20 - 25 °C

With pivaloyl chloride; levamisole hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; chloroform;
DOI:10.1021/ja109975c