3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-amine

Base Information

• Chemical Name: 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-amine
• CAS No.: 481048-61-7
• Molecular Formula: C₂₂H₂₁FN₆
• Molecular Weight: 388.447
• Mol file: 481048-61-7.mol

Synonyms:3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-amine

Chemical Property of 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-amine

There total 9 articles about 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide (481049-30-3) → 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-amine (481048-61-7)

Guidance literature:

With sodium hydroxide; In methanol; for 6h; Heating;

DOI:10.1021/ol0343616

Reference yield:

2-amino-3-nitropyridine (4214-75-9) → 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-amine (481048-61-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 36 percent / dimethylformamide / 6 h / Heating

2: 55 percent / aq. H₂SO₄ / 1 h / Heating

3: 80 percent / Fe; aq. NH₄Cl / methanol / 10 h / Heating

4: 62 percent / 144 h / Heating

5: 57 percent / K₂CO₃ / ethanol / 16 h / 80 °C

6: 88 percent / aq. NaOH / methanol / 6 h / Heating

With sodium hydroxide; sulfuric acid; iron; potassium carbonate; ammonium chloride; In methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ol0343616

Reference yield:

2-bromo-4'-fluoroacetophenone (403-29-2) → 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-amine (481048-61-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 36 percent / dimethylformamide / 6 h / Heating

2: 55 percent / aq. H₂SO₄ / 1 h / Heating

3: 80 percent / Fe; aq. NH₄Cl / methanol / 10 h / Heating

4: 62 percent / 144 h / Heating

5: 57 percent / K₂CO₃ / ethanol / 16 h / 80 °C

6: 88 percent / aq. NaOH / methanol / 6 h / Heating

With sodium hydroxide; sulfuric acid; iron; potassium carbonate; ammonium chloride; In methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ol0343616

upstream raw materials:

N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

2-amino-3-nitropyridine

Cyclopentamine

2-bromo-4'-fluoroacetophenone