N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

Base Information

• Chemical Name: N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide
• CAS No.: 481049-30-3
• Molecular Formula: C₂₅H₂₆FN₇
• Molecular Weight: 443.527
• Mol file: 481049-30-3.mol

Synonyms:N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

Chemical Property of N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

There total 7 articles about N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N-cyclopentyl-N'-guanidine hydrochloride + N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide (481049-29-0) → N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide (481049-30-3)

Guidance literature:

With potassium carbonate; In ethanol; at 80 ℃; for 16h;

DOI:10.1021/ol0343616

Reference yield:

2-amino-3-nitropyridine (4214-75-9) → N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide (481049-30-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 36 percent / dimethylformamide / 6 h / Heating

2: 55 percent / aq. H₂SO₄ / 1 h / Heating

3: 80 percent / Fe; aq. NH₄Cl / methanol / 10 h / Heating

4: 62 percent / 144 h / Heating

5: 57 percent / K₂CO₃ / ethanol / 16 h / 80 °C

With sulfuric acid; iron; potassium carbonate; ammonium chloride; In methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ol0343616

Reference yield:

2-bromo-4'-fluoroacetophenone (403-29-2) → N'-[3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide (481049-30-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 36 percent / dimethylformamide / 6 h / Heating

2: 55 percent / aq. H₂SO₄ / 1 h / Heating

3: 80 percent / Fe; aq. NH₄Cl / methanol / 10 h / Heating

4: 62 percent / 144 h / Heating

5: 57 percent / K₂CO₃ / ethanol / 16 h / 80 °C

With sulfuric acid; iron; potassium carbonate; ammonium chloride; In methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ol0343616

upstream raw materials:

N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

2-amino-3-nitropyridine

Cyclopentamine

2-bromo-4'-fluoroacetophenone

Downstream raw materials:

3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-amine