1-(2-Ethylthiobenzyl)pyrrole-2-carboxyamide

Base Information

• Chemical Name: 1-(2-Ethylthiobenzyl)pyrrole-2-carboxyamide
• CAS No.: 107096-50-4
• Molecular Formula: C₁₄H₁₆N₂OS
• Molecular Weight: 260.36
• Mol file: 107096-50-4.mol

Synonyms:1-(2-Ethylthiobenzyl)pyrrole-2-carboxyamide

Chemical Property of 1-(2-Ethylthiobenzyl)pyrrole-2-carboxyamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-Ethylthiobenzyl)pyrrole-2-carboxyamide

There total 10 articles about 1-(2-Ethylthiobenzyl)pyrrole-2-carboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(2-mercaptobenzyl)pyrrole-2-carboxyamide (99141-25-0) + ethyl iodide (75-03-6) → 1-(2-Ethylthiobenzyl)pyrrole-2-carboxyamide (107096-50-4)

Guidance literature:

With sodium ethanolate; In tetrahydrofuran; for 5h; Ambient temperature;

Reference yield: 78.0%

1-(2-Ethylthiobenzyl)pyrrole-2-carbonitrile (107096-49-1) → 1-(2-Ethylthiobenzyl)pyrrole-2-carboxyamide (107096-50-4)

Guidance literature:

With sodium hydroxide; In ethanol; for 24h; Heating;

Reference yield:

2-methylmercaptobenzyl bromide (89981-01-1) → 1-(2-Ethylthiobenzyl)pyrrole-2-carboxyamide (107096-50-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 93 percent / K / tetrahydrofuran / 8 h / Heating

2: 83 percent / Hydroxylamine hydrochloride, aq.Na₂CO₃ / methanol / 2 h / Heating

3: 87 percent / Acetic anhydride / 2 h / 140 °C

4: 88 percent / Potassium hydroxide / aq. ethanol / 12 h / Heating

5: 81 percent / Sodium / N,N-dimethyl-acetamide / 15 h / 95 - 100 °C

6: 98 percent / Sodium ethoxide / tetrahydrofuran / 5 h / Ambient temperature

With potassium hydroxide; hydroxylamine hydrochloride; sodium ethanolate; sodium; potassium; acetic anhydride; sodium carbonate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl acetamide;

upstream raw materials:

1-(2-Ethylthiobenzyl)pyrrole-2-carbonitrile

1-(2-mercaptobenzyl)pyrrole-2-carboxyamide

ethyl iodide

2-pyrrole aldehyde

Downstream raw materials:

1-(2-Ethylthiobenzyl)pyrrole-2-carboxylic acid

1-(2-Ethylthiobenzyl)pyrrole-2-carbonitrile