89981-01-1Relevant articles and documents
Palladium-Catalyzed C-S Bond Formation as a Tool for Latent-Active Glycosylation
Hedberg, Christinne,Jessen, Kamilla S.,Hansson, Rikke F.,Heuckendorff, Mads,Jensen, Henrik H.
, p. 7068 - 7072 (2020/10/02)
A high-yielding palladium-catalyzed C-S cross-coupling is presented for utilization in carbohydrate chemistry as a key transformation for attachment of a second chelating sulfur atom that allows the exploitation of a latent-active glycosylation strategy w
Nickel-Catalyzed Inter- and Intramolecular Aryl Thioether Metathesis by Reversible Arylation
Delcaillau, Tristan,Bismuto, Alessandro,Lian, Zhong,Morandi, Bill
, p. 2110 - 2114 (2019/12/24)
A nickel-catalyzed aryl thioether metathesis has been developed to access high-value thioethers. 1,2-Bis(dicyclohexylphosphino)ethane (dcype) is essential to promote this highly functional-group-tolerant reaction. Furthermore, synthetically challenging macrocycles could be obtained in good yield in an unusual example of ring-closing metathesis that does not involve alkene bonds. In-depth organometallic studies support a reversible Ni0/NiII pathway to product formation. Overall, this work not only provides a more sustainable alternative to previous catalytic systems based on Pd, but also presents new applications and mechanistic information that are highly relevant to the further development and application of unusual single-bond metathesis reactions.
Syntheses, structures, and catalytic activities of hemilabile thioether-functionalized NHC complexes
Huynh, Han Vinh,Yeo, Chun Hui,Chew, Ying Xia
experimental part, p. 1479 - 1486 (2010/05/15)
Four imidazolium (5a/b) and benzimidazolium (6a/b) salts with hemilabile alkyl-aryl thioether functions have been prepared via a straightforward and modular pathway in order to compare their reactivities toward palladation. Reaction of 5a/b with Pd(OAc)s
Hemilabile behavior of a thioether-functionalized N-heterocyclic carbene ligand
Huynh, Han Vinh,Yeo, Chun Hui,Tan, Geok Kheng
, p. 3833 - 3835 (2007/10/03)
The truely hemilabile nature of a novel thioether-functionalized N-heterocyclic carbene ligand is demonstrated in a range of Pd(ii) complexes. The Royal Society of Chemistry 2006.
5-Benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators
Zhi, Lin,Tegley, Christopher M.,Pio, Barbara,Edwards, James P.,Motamedi, Mehrnouch,Jones, Todd K.,Marschke, Keith B.,Mais, Dale E.,Risek, Boris,Schrader, William T.
, p. 4104 - 4112 (2007/10/03)
A series of 5-benylidene-1,2-dihydrochromeno[3,4-f]quinolines (4) were synthesized and tested in bioassays to evaluate their progestational activities, receptor- and tissue-selectivity profiles as selective progesterone receptor modulators (SPRMs). Most of the new analogues exhibited as highly potent progestins with more than 100-fold receptor selectivity over other steroid hormone receptors and LG120920 (7b) demonstrated tissue selectivity toward uterus and vagina versus breasts in a rodent model after oral administration.
