N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide
CAS No.:1415829-52-5
Molecular Formula:C₂₁H₂₀N₄O₂S
Molecular Weight:392.481
Hs Code.:

Synonyms:N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide

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Technology Process of N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide

There total 3 articles about N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1415830-38-4
8-chloro-2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine

: 70-55-3
toluene-4-sulfonamide

: 1415829-52-5
N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In toluene; for 21h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2014.09.036

Reference yield:

: 5379-16-8
3,5-dimethylacetophenone

: 1415829-52-5
N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium hydrobromide perbromide / chloroform; ethanol / 17 h / 50 °C

2: sodium hydrogencarbonate; tert-butyl alcohol / 40 h / Reflux; Inert atmosphere

3: caesium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / toluene / 21 h / Reflux; Inert atmosphere

With pyridinium hydrobromide perbromide; sodium hydrogencarbonate; caesium carbonate; tert-butyl alcohol; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In ethanol; chloroform; toluene;

Reference yield:

: 154226-77-4
2-bromo-1-(3,5-dimethylphenyl)ethan-1-one

: 1415829-52-5
N-[2-(3,5-dimethylphenyl)imidazo[1,2-a]pyrazine-8-yl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; tert-butyl alcohol / 40 h / Reflux; Inert atmosphere

2: caesium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / toluene / 21 h / Reflux; Inert atmosphere

With sodium hydrogencarbonate; caesium carbonate; tert-butyl alcohol; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In toluene;