ethyl 7-chloro-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

Base Information

Chemical Name:ethyl 7-chloro-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate
CAS No.:1207455-29-5
Molecular Formula:C₂₂H₂₀ClN₃O₃
Molecular Weight:409.872
Hs Code.:

Synonyms:ethyl 7-chloro-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

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Chemical Property of ethyl 7-chloro-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

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Technology Process of ethyl 7-chloro-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

There total 8 articles about ethyl 7-chloro-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1207455-28-4
(E)-4-(benzylideneamino)-6-chloroisobenzofuran-1(3H)-one

: 141-52-6
sodium ethanolate

: 13750-81-7
N-methyl-2-imidazolcarboxaldehyde

: 1207455-29-5
ethyl 7-chloro-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

Guidance literature:: In Ethyl propionate; at 20 ℃; for 3h;

Reference yield:

: 1207455-28-4
(E)-4-(benzylideneamino)-6-chloroisobenzofuran-1(3H)-one

: 141-52-6
sodium ethanolate

: 105-37-3,20741-13-3
Ethyl propionate

: 13750-81-7
N-methyl-2-imidazolcarboxaldehyde

: 1207455-29-5
ethyl 7-chloro-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

Guidance literature:: at 20 ℃; for 3h;

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1207455-29-5
ethyl 7-chloro-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / nitric acid / 3.5 h / -5 - 0 °C

2: sulfuric acid / 16 h / 0 °C / Reflux

3: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

4: 1,4-dioxane; water / 96 h / Reflux

5: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr

6: magnesium sulfate / dichloromethane / Reflux

7: 3 h / 20 °C

With N-Bromosuccinimide; sulfuric acid; hydrogen; magnesium sulfate; dibenzoyl peroxide; palladium 10% on activated carbon; nitric acid; In 1,4-dioxane; tetrachloromethane; dichloromethane; water; ethyl acetate;