2-(o-chlorobenzoyl)-4-nitro-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide

Base Information

• Chemical Name: 2-(o-chlorobenzoyl)-4-nitro-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide
• CAS No.: 76337-74-1
• Molecular Formula: C₂₆H₂₃ClN₄O₇
• Molecular Weight: 538.944

Synonyms:2-(o-chlorobenzoyl)-4-nitro-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide

Chemical Property of 2-(o-chlorobenzoyl)-4-nitro-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide

Chemical Property:

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Technology Process of 2-(o-chlorobenzoyl)-4-nitro-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide

There total 3 articles about 2-(o-chlorobenzoyl)-4-nitro-N-methyl-N^α-<(benzyloxycarbonyl)glycyl>glycinanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{[2-(2-Chloro-benzoyl)-4-nitro-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester (76337-80-9) → 2-(o-chlorobenzoyl)-4-nitro-N-methyl-Nα-<(benzyloxycarbonyl)glycyl>glycinanilide (76337-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, oil, 2-5 deg C, 15 min, 2.) DMF, oil, 2-5 deg C, 2 h

2: 100 percent / 20percent HBr / acetic acid / 1 h / Ambient temperature

3: hexamethylphosphoric acid triamide; acetonitrile / 5 h / Ambient temperature

With hydrogen bromide; sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetic acid; acetonitrile;

DOI:10.1021/jm00133a006

Reference yield:

({[2-(2-Chloro-benzoyl)-4-nitro-phenyl]-methyl-carbamoyl}-methyl)-carbamic acid benzyl ester (76337-83-2) → 2-(o-chlorobenzoyl)-4-nitro-N-methyl-Nα-<(benzyloxycarbonyl)glycyl>glycinanilide (76337-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 20percent HBr / acetic acid / 1 h / Ambient temperature

2: hexamethylphosphoric acid triamide; acetonitrile / 5 h / Ambient temperature

With hydrogen bromide; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetic acid; acetonitrile;

DOI:10.1021/jm00133a006

Reference yield:

N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) + 2-Amino-N-[2-(2-chloro-benzoyl)-4-nitro-phenyl]-N-methyl-acetamide; hydrobromide (76337-75-2) → 2-(o-chlorobenzoyl)-4-nitro-N-methyl-Nα-<(benzyloxycarbonyl)glycyl>glycinanilide (76337-74-1)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile; for 5h; Yield given; Ambient temperature;

DOI:10.1021/jm00133a006

upstream raw materials:

N-(benzyloxycarbonyl)glycyl chloride

2-Amino-N-[2-(2-chloro-benzoyl)-4-nitro-phenyl]-N-methyl-acetamide; hydrobromide

{[2-(2-Chloro-benzoyl)-4-nitro-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester

({[2-(2-Chloro-benzoyl)-4-nitro-phenyl]-methyl-carbamoyl}-methyl)-carbamic acid benzyl ester

Downstream raw materials:

2-(o-chlorobenzoyl)-4-nitro-N-methyl-N^α-glycylglycinanilide

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