4-cyano-4-(4-methylphenyl)-4-morpholino-N-methoxy-N-methylbutyramide

Base Information

• Chemical Name: 4-cyano-4-(4-methylphenyl)-4-morpholino-N-methoxy-N-methylbutyramide
• CAS No.: 364045-21-6
• Molecular Formula: C₁₈H₂₅N₃O₃
• Molecular Weight: 331.415
• Mol file: 364045-21-6.mol

Synonyms:4-cyano-4-(4-methylphenyl)-4-morpholino-N-methoxy-N-methylbutyramide

Chemical Property of 4-cyano-4-(4-methylphenyl)-4-morpholino-N-methoxy-N-methylbutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-cyano-4-(4-methylphenyl)-4-morpholino-N-methoxy-N-methylbutyramide

There total 1 articles about 4-cyano-4-(4-methylphenyl)-4-morpholino-N-methoxy-N-methylbutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

morpholin-4-yl-p-tolyl-acetonitrile (42419-53-4) + N-methyl-N-methoxy-3-bromopropionamide (128562-58-3) → 4-cyano-4-(4-methylphenyl)-4-morpholino-N-methoxy-N-methylbutyramide (364045-21-6)

Guidance literature:

morpholin-4-yl-p-tolyl-acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-methyl-N-methoxy-3-bromopropionamide; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1016/S0040-4020(01)00571-3

Reference yield:

4-cyano-4-(4-methylphenyl)-4-morpholino-N-methoxy-N-methylbutyramide (364045-21-6) → 1-(4-methoxyphenyl)-4-(4-methylphenyl)-1,4-butanedione (364045-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1.5 h

2: CuSO₄*5H₂O / methanol / 3 h / Heating

With copper(II) sulfate; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4020(01)00571-3

Reference yield:

4-methoxyphenyl magnesium bromide (13139-86-1) + 4-cyano-4-(4-methylphenyl)-4-morpholino-N-methoxy-N-methylbutyramide (364045-21-6) → 5-(4-methoxy-phenyl)-2-morpholin-4-yl-5-oxo-2-p-tolyl-pentanenitrile

Guidance literature:

In tetrahydrofuran; for 1.5h;

DOI:10.1016/S0040-4020(01)00571-3

upstream raw materials:

morpholin-4-yl-p-tolyl-acetonitrile

N-methyl-N-methoxy-3-bromopropionamide

Downstream raw materials:

1-(4-methoxyphenyl)-4-(4-methylphenyl)-1,4-butanedione