(S)-(+)-N-methyl-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(S)-(+)-N-methyl-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:159465-35-7
Molecular Formula:C₁₇H₁₈BrNO
Molecular Weight:332.24
Hs Code.:

Synonyms:(S)-(+)-N-methyl-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of (S)-(+)-N-methyl-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(+)-N-methyl-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (S)-(+)-N-methyl-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

There total 7 articles about (S)-(+)-N-methyl-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 159572-24-4
(S)-(-)-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

: 159465-35-7
(S)-(+)-N-methyl-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With formic acid; for 4h; Heating;
DOI:10.1021/jm00051a008

Reference yield:

: 159465-27-7
3-Bromo-4-methoxyphenethylamine

: 159465-35-7
(S)-(+)-N-methyl-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / 20percent NaOH / diethyl ether / Ambient temperature

2: 14 percent / P₂O₅, POCl₃ / xylene / 6 h / Heating

3: 57 percent / acetic acid, NaBH₄ / methanol / 1.) RT, 1 h, 2.) 50 deg C, 4 h

5: 87 percent / 98percent formic acid / 4 h / Heating

With sodium hydroxide; sodium tetrahydroborate; formic acid; phosphorus pentoxide; acetic acid; trichlorophosphate; In methanol; diethyl ether; xylene;
DOI:10.1021/jm00051a008

Reference yield:

: 98-88-4
benzoyl chloride

: 159465-35-7
(S)-(+)-N-methyl-6-bromo-7-methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / 20percent NaOH / diethyl ether / Ambient temperature

2: 14 percent / P₂O₅, POCl₃ / xylene / 6 h / Heating

3: 57 percent / acetic acid, NaBH₄ / methanol / 1.) RT, 1 h, 2.) 50 deg C, 4 h

5: 87 percent / 98percent formic acid / 4 h / Heating

With sodium hydroxide; sodium tetrahydroborate; formic acid; phosphorus pentoxide; acetic acid; trichlorophosphate; In methanol; diethyl ether; xylene;
DOI:10.1021/jm00051a008