4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllotoxin 13-alcohol

Base Information

Chemical Name:4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllotoxin 13-alcohol
CAS No.:153230-71-8
Molecular Formula:C₃₃H₅₀O₈Si₂
Molecular Weight:630.926
Hs Code.:

Synonyms:4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllotoxin 13-alcohol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllotoxin 13-alcohol

Chemical Property:

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Technology Process of 4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllotoxin 13-alcohol

There total 3 articles about 4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllotoxin 13-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 153230-70-7
4,4'-bis-O-(dimethyl-tert-butylsilyl)-4'-O-demethylepipodophyllotoxin

: 153230-71-8
4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllotoxin 13-alcohol

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 0.333333h;

Reference yield:

: 6559-91-7
4'-demethylepipodophyllotoxin

: 153230-71-8
4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllotoxin 13-alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / imidazole / dimethylformamide / 20 h

2: 67 percent / diisobutylaluminum hydride / toluene; hexane / 0.33 h / -78 °C

With 1H-imidazole; diisobutylaluminium hydride; In hexane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 153230-71-8
4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllotoxin 13-alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / imidazole / dimethylformamide / 20 h

2: 67 percent / diisobutylaluminum hydride / toluene; hexane / 0.33 h / -78 °C

With 1H-imidazole; diisobutylaluminium hydride; In hexane; N,N-dimethyl-formamide; toluene;