(5S,1'S)-5-(2'-cyclohexyl-1'-methanesulfonyloxyethyl)dihydrofuran-2(3H)-one

Base Information

Chemical Name:(5S,1'S)-5-(2'-cyclohexyl-1'-methanesulfonyloxyethyl)dihydrofuran-2(3H)-one
CAS No.:137530-20-2
Molecular Formula:C₁₃H₂₂O₅S
Molecular Weight:290.381
Hs Code.:

Synonyms:(5S,1'S)-5-(2'-cyclohexyl-1'-methanesulfonyloxyethyl)dihydrofuran-2(3H)-one

Suppliers and Price of (5S,1'S)-5-(2'-cyclohexyl-1'-methanesulfonyloxyethyl)dihydrofuran-2(3H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S,1'S)-5-(2'-cyclohexyl-1'-methanesulfonyloxyethyl)dihydrofuran-2(3H)-one

Chemical Property:

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Technology Process of (5S,1'S)-5-(2'-cyclohexyl-1'-methanesulfonyloxyethyl)dihydrofuran-2(3H)-one

There total 10 articles about (5S,1'S)-5-(2'-cyclohexyl-1'-methanesulfonyloxyethyl)dihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 124-63-0
methanesulfonyl chloride

: 137530-19-9
(5S,1'S)-5-(2'-cyclohexyl-1'-hydroxyethyl)dihydrofuran-2(3H)-one

: 137530-20-2
(5S,1'S)-5-(2'-cyclohexyl-1'-methanesulfonyloxyethyl)dihydrofuran-2(3H)-one

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1039/c39920001562

Reference yield:

: 16666-81-2
cyclohexyltriphenylphosphorane

: 137530-20-2
Methanesulfonic acid (R)-2-cyclohexyl-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 1) -30 deg C, 0.5h, 2) RT, 7h

2: H₂ / Raney Ni / ethanol

3: pyridine / 0.25 h / -15 °C

4: 78 percent / DMPU / tetrahydrofuran / 0.08 h / -78 °C

5: 95 percent / 30percent aq. TFA / 1 h / Ambient temperature

6: pyridine

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hydrogen; trifluoroacetic acid; nickel; In tetrahydrofuran; ethanol;
DOI:10.1016/0040-4039(91)80024-Z

Reference yield:

: ((4S,5R)-5-Cyclohexylidenemethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol

: 137530-20-2
Methanesulfonic acid (R)-2-cyclohexyl-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Raney Ni / ethanol

2: pyridine / 0.25 h / -15 °C

3: 78 percent / DMPU / tetrahydrofuran / 0.08 h / -78 °C

4: 95 percent / 30percent aq. TFA / 1 h / Ambient temperature

5: pyridine

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hydrogen; trifluoroacetic acid; nickel; In tetrahydrofuran; ethanol;
DOI:10.1016/0040-4039(91)80024-Z