(3R,4R)-tert-butyl 4-(benzoyloxymethyl)-3-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(3R,4R)-tert-butyl 4-(benzoyloxymethyl)-3-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate
CAS No.:1242166-93-3
Molecular Formula:C₂₃H₃₇NO₅Si
Molecular Weight:435.636
Hs Code.:

Synonyms:(3R,4R)-tert-butyl 4-(benzoyloxymethyl)-3-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate

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Chemical Property of (3R,4R)-tert-butyl 4-(benzoyloxymethyl)-3-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate

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Technology Process of (3R,4R)-tert-butyl 4-(benzoyloxymethyl)-3-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate

There total 3 articles about (3R,4R)-tert-butyl 4-(benzoyloxymethyl)-3-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1011300-20-1
(3R,4R)-tert-butyl 4-(benzoyloxymethyl)-3-hydroxypyrrolidine-1-carboxylate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1242166-93-3
(3R,4R)-tert-butyl 4-(benzoyloxymethyl)-3-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 17h;
DOI:10.1021/jm100898v

Reference yield:

: 98-88-4
benzoyl chloride

: 1242166-93-3
(3R,4R)-tert-butyl 4-(benzoyloxymethyl)-3-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: di(n-butyl)tin oxide / toluene / 1 h / Reflux; Dean-Stark apparatus

1.2: 17 h / 5 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 17 h / 20 °C

With 1H-imidazole; di(n-butyl)tin oxide; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 635319-09-4
tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1242166-93-3
(3R,4R)-tert-butyl 4-(benzoyloxymethyl)-3-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: di(n-butyl)tin oxide / toluene / 1 h / Reflux; Dean-Stark apparatus

1.2: 17 h / 5 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 17 h / 20 °C

With 1H-imidazole; di(n-butyl)tin oxide; In N,N-dimethyl-formamide; toluene;