(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid

Base Information

Chemical Name:(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid
CAS No.:1384457-44-6
Molecular Formula:C₁₉H₂₀O₃
Molecular Weight:296.366
Hs Code.:

Synonyms:(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid

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Chemical Property of (2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid

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Technology Process of (2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid

There total 7 articles about (2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1384457-45-7
(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid (R)-1-phenylethylamine salt

: 1384457-44-6
(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid

Guidance literature:: With hydrogenchloride; In tert-butyl methyl ether; water; at 20 ℃; for 0.25h;

Reference yield:

: 100-39-0
benzyl bromide

: 1384457-44-6
(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N-benzyl-N,N,N-triethylammonium chloride / N,N-dimethyl-formamide / 22 h / 80 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / -10 - 0 °C / Inert atmosphere

2.2: 5 °C

3.1: carbon tetrabromide / 10.33 h / 62 °C / Inert atmosphere

4.1: triethylamine; lithium hexamethyldisilazane / toluene / 2.5 h / -65 °C / Inert atmosphere

4.2: 0.17 h / 20 - 30 °C

4.3: pH 1 - 2 / Cooling with ice

5.1: ethanol / 20 - 40 °C / Resolution of racemate; Reflux

6.1: hydrogenchloride / water; tert-butyl methyl ether / 0.25 h / 20 °C

With hydrogenchloride; diisobutylaluminium hydride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; carbon tetrabromide; N-benzyl-N,N,N-triethylammonium chloride; In ethanol; tert-butyl methyl ether; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 208836-69-5
3-(3'-benzyloxyphenyl)-(E)-propenoic acid ethyl ester

: 1384457-44-6
(2R,3R)-3-(3-benzyloxyphenyl)-2-methylpent-4-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / toluene / -10 - 0 °C / Inert atmosphere

1.2: 5 °C

2.1: carbon tetrabromide / 10.33 h / 62 °C / Inert atmosphere

3.1: triethylamine; lithium hexamethyldisilazane / toluene / 2.5 h / -65 °C / Inert atmosphere

3.2: 0.17 h / 20 - 30 °C

3.3: pH 1 - 2 / Cooling with ice

4.1: ethanol / 20 - 40 °C / Resolution of racemate; Reflux

5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.25 h / 20 °C

With hydrogenchloride; diisobutylaluminium hydride; triethylamine; lithium hexamethyldisilazane; carbon tetrabromide; In ethanol; tert-butyl methyl ether; water; toluene;