8-(4-Chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Base Information

Chemical Name:8-(4-Chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
CAS No.:1319068-94-4
Molecular Formula:C₁₅H₁₃ClN₄
Molecular Weight:284.748
Hs Code.:

Synonyms:8-(4-Chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-(4-Chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

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Technology Process of 8-(4-Chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

There total 6 articles about 8-(4-Chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1319068-92-2
8-bromo-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

: 1679-18-1
4-Chlorophenylboronic acid

: 1319068-94-4
8-(4-Chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 1.5h; Inert atmosphere;

Reference yield: 61.0%

: 1319068-92-2
8-bromo-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

: 1329672-66-3
1-(2-amino-8-bromo-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-ethanone

: 1679-18-1
4-Chlorophenylboronic acid

: 1319068-94-4
8-(4-Chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1319068-94-4
8-(4-Chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 16 h / 80 °C / Inert atmosphere

2: bromine / chloroform / 18 h / 20 °C

3: 1,4-dioxane / 6 h / 20 °C / Inert atmosphere

4: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 6 h / 20 °C / Inert atmosphere

5: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.5 h / 80 °C / Inert atmosphere

With potassium phosphate; hydroxylamine hydrochloride; bromine; sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; tricyclohexylphosphine; In 1,4-dioxane; methanol; chloroform; water; toluene;