(S)-3-Amino-3-isobutyl-dihydro-furan-2-one

Base Information

Chemical Name:(S)-3-Amino-3-isobutyl-dihydro-furan-2-one
CAS No.:288403-75-8
Molecular Formula:C₈H₁₅NO₂
Molecular Weight:157.213
Hs Code.:

Synonyms:(S)-3-Amino-3-isobutyl-dihydro-furan-2-one

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Chemical Property of (S)-3-Amino-3-isobutyl-dihydro-furan-2-one

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Technology Process of (S)-3-Amino-3-isobutyl-dihydro-furan-2-one

There total 4 articles about (S)-3-Amino-3-isobutyl-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 288404-46-6
((S)-3-Isobutyl-2-oxo-tetrahydro-furan-3-yl)-carbamic acid benzyl ester

: 288403-75-8
(S)-3-Amino-3-isobutyl-dihydro-furan-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 1h;
DOI:10.1021/ol0059293

Reference yield:

: 145452-11-5
(S)-2-Amino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

: 288403-75-8
(S)-3-Amino-3-isobutyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: i-Pr₂NEt / tetrahydrofuran / 4 h / 20 °C

2: O₃; Ph₃P / CH₂Cl₂ / -78 °C

3: 80 percent / NaBH₃CN; aq. HCl / methanol / 3 h / 20 °C

4: 84 percent / H₂ / Pd(C) / ethanol / 1 h

With hydrogenchloride; hydrogen; sodium cyanoborohydride; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1: benzyloxycarbonylation / 2: Oxidation / 3: Reduction / 4: Hydrogenation;
DOI:10.1021/ol0059293

Reference yield:

: 219585-99-6
(S)-2-Benzyloxycarbonylamino-4-methyl-2-(2-oxo-ethyl)-pentanoic acid methyl ester

: 288403-75-8
(S)-3-Amino-3-isobutyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NaBH₃CN; aq. HCl / methanol / 3 h / 20 °C

2: 84 percent / H₂ / Pd(C) / ethanol / 1 h

With hydrogenchloride; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In methanol; ethanol; 1: Reduction / 2: Hydrogenation;
DOI:10.1021/ol0059293