methyl (2S)-cyclohexyl-{[(4-fluoro-2-nitrophenyl)carbonyl]amino}ethanoate

Base Information

• Chemical Name: methyl (2S)-cyclohexyl-{[(4-fluoro-2-nitrophenyl)carbonyl]amino}ethanoate
• CAS No.: 887243-08-5
• Molecular Formula: C₁₆H₁₉FN₂O₅
• Molecular Weight: 338.336

Synonyms:methyl (2S)-cyclohexyl-{[(4-fluoro-2-nitrophenyl)carbonyl]amino}ethanoate

Chemical Property of methyl (2S)-cyclohexyl-{[(4-fluoro-2-nitrophenyl)carbonyl]amino}ethanoate

Chemical Property:

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Technology Process of methyl (2S)-cyclohexyl-{[(4-fluoro-2-nitrophenyl)carbonyl]amino}ethanoate

There total 2 articles about methyl (2S)-cyclohexyl-{[(4-fluoro-2-nitrophenyl)carbonyl]amino}ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-fluoro-2-nitrobenzoic acid (394-01-4) + methyl (2S)-amino(cyclohexyl)ethanoate hydrochloride (14328-63-3,14328-64-4) → methyl (2S)-cyclohexyl-{[(4-fluoro-2-nitrophenyl)carbonyl]amino}ethanoate (887243-08-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

4-fluoro-2-nitrobenzoic acid (394-01-4) + (S)-amino(cyclohexyl)acetic acid methyl ester (145618-11-7) → methyl (2S)-cyclohexyl-{[(4-fluoro-2-nitrophenyl)carbonyl]amino}ethanoate (887243-08-5)

Guidance literature:

With N,N-diethyl-N-isopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2008.12.085

Reference yield: 83.0%

methyl (2S)-cyclohexyl-{[(4-fluoro-2-nitrophenyl)carbonyl]amino}ethanoate (887243-08-5) → methyl (2S)-{[(2-amino-4-fluorophenyl)carbonyl]amino}(cyclohexyl)-ethanoate (887243-09-6)

Guidance literature:

With hydrogen; 5% palladium over charcoal; In ethanol; for 1h; under 2585.81 Torr;

upstream raw materials:

4-fluoro-2-nitrobenzoic acid

methyl (2S)-amino(cyclohexyl)ethanoate hydrochloride

(S)-amino(cyclohexyl)acetic acid methyl ester

Downstream raw materials:

methyl (2S)-{[(2-amino-4-fluorophenyl)carbonyl]amino}(cyclohexyl)-ethanoate

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