145618-11-7Relevant articles and documents
Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability
Zwicker, Jeffery D.,Diaz, Nicolas A.,Guerra, Alfredo J.,Kirchhoff, Paul D.,Wen, Bo,Sun, Duxin,Carruthers, Vern B.,Larsen, Scott D.
supporting information, p. 1972 - 1980 (2018/04/14)
The neurotropic protozoan Toxoplasma gondii is the second leading cause of death due to foodborne illness in the US, and has been designated as one of five neglected parasitic infections by the Center for Disease Control and Prevention. Currently, no trea
Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination
Su, Cunxiang,Xie, Ying,Pan, Hongjie,Liu, Mao,Tian, Hua,Shi, Yian
, p. 5856 - 5860 (2014/08/05)
This paper describes an efficient asymmetric biomimetic transamination of α-keto esters with a quinine-derived chiral base as the catalyst, giving a variety of β-branched α-amino esters in 50-96% yield and 87-95% ee. This journal is the Partner Organisations 2014.
Rhodium/graphite-catalyzed hydrogenation of carbocyclic and heterocyclic aromatic compounds
Falini, Giuseppe,Gualandi, Andrea,Savoia, Diego
experimental part, p. 2440 - 2446 (2010/02/27)
Rhodium on graphite (Rh/Gr, C24Rh) was prepared by reaction of anhydrous rhodium trichloride with potassium graphite (C8K, 3 equivalents) and used as a heterogeneous catalyst for the hydrogenation of carbocyclic and heterocyclic aromatic compounds at room temperature and 1 atm of hydrogen pressure. The effect of substitution on the benzene ring was examined in a variety of derivatives, including those with alkyl, hydroxy, alkoxy, aryloxy, carboxy, amino, nitro, acyl, chloro, or functionalized alkyl groups. Reduction of carbonyl functions of aromatic aldehydes and ketones occurred with complete or partial cleavage of the benzylic C-O bond; this cleavage also occurred in the hydrogenation of benzylic alcohols and esters. Georg Thieme Verlag Stuttgart.