4-(4-fluorophenyl)-1-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:4-(4-fluorophenyl)-1-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester
CAS No.:1353046-98-6
Molecular Formula:C₂₀H₁₆FNO₄
Molecular Weight:353.35
Hs Code.:

Synonyms:4-(4-fluorophenyl)-1-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester

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Chemical Property of 4-(4-fluorophenyl)-1-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester

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Technology Process of 4-(4-fluorophenyl)-1-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester

There total 3 articles about 4-(4-fluorophenyl)-1-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 75-52-5
nitromethane

: 459-57-4
4-fluorobenzaldehyde

: 62-53-3
aniline

: 762-42-5
dimethyl acetylenedicarboxylate

: 1353046-98-6
4-(4-fluorophenyl)-1-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester

Guidance literature:: With iodine; for 8h; Reflux;
DOI:10.1055/s-0030-1260228

Reference yield:

: 405-99-2
para-fluorostyrene

: 4916-29-4,10567-58-5,54494-74-5
dimethyl 2-(phenyl-amino)-2-butendioate

: 1353046-98-6
4-(4-fluorophenyl)-1-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester

Guidance literature:: With dipotassium peroxodisulfate; palladium diacetate; acetic acid; In acetonitrile; at 100 ℃; for 20h; regioselective reaction;
DOI:10.1021/acs.orglett.6b02325

Reference yield:

: 62-53-3
aniline

: 1353046-98-6
4-(4-fluorophenyl)-1-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 0.17 h / 20 °C

2: palladium diacetate; dipotassium peroxodisulfate; acetic acid / acetonitrile / 20 h / 100 °C

With dipotassium peroxodisulfate; palladium diacetate; acetic acid; In acetonitrile;
DOI:10.1021/acs.orglett.6b02325