N-(2,6-diethylphenyl)-8-[(1-{[2-(dimethylamino)ethyl]sulfonyl}piperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Base Information

Chemical Name:N-(2,6-diethylphenyl)-8-[(1-{[2-(dimethylamino)ethyl]sulfonyl}piperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
CAS No.:1202056-25-4
Molecular Formula:C₃₀H₄₂N₈O₃S
Molecular Weight:594.781
Hs Code.:

N-(2,6-diethylphenyl)-8-[(1-{[2-(dimethylamino)ethyl]sulfonyl}piperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Synonyms:N-(2,6-diethylphenyl)-8-[(1-{[2-(dimethylamino)ethyl]sulfonyl}piperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

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Chemical Property of N-(2,6-diethylphenyl)-8-[(1-{[2-(dimethylamino)ethyl]sulfonyl}piperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

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Technology Process of N-(2,6-diethylphenyl)-8-[(1-{[2-(dimethylamino)ethyl]sulfonyl}piperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

There total 6 articles about N-(2,6-diethylphenyl)-8-[(1-{[2-(dimethylamino)ethyl]sulfonyl}piperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1202056-06-1
N-(2,6-diethylphenyl)-8-{[1-(ethenylsulfonyl)piperidin-4-yl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

: 124-40-3
dimethyl amine

: 1202056-25-4
N-(2,6-diethylphenyl)-8-[(1-{[2-(dimethylamino)ethyl]sulfonyl}piperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Guidance literature:: In ethanol; water; at 20 ℃; for 0.5h;

Reference yield:

: 579-66-8
2,6-diethylaniline

: 1202056-25-4
N-(2,6-diethylphenyl)-8-[(1-{[2-(dimethylamino)ethyl]sulfonyl}piperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 3.67 h / 0 - 20 °C

2: sodium tris(acetoxy)borohydride; trifluoroacetic acid / N,N-dimethyl-formamide / 20 h

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C / Inert atmosphere; Molecular sieve

5: ethanol; water / 0.5 h / 20 °C

With hydrogenchloride; sodium hexamethyldisilazane; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1034614-14-6
potassium 8-amino-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid

: 1202056-25-4
N-(2,6-diethylphenyl)-8-[(1-{[2-(dimethylamino)ethyl]sulfonyl}piperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: sodium tris(acetoxy)borohydride; trifluoroacetic acid / N,N-dimethyl-formamide / 20 h

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C / Inert atmosphere; Molecular sieve

5: ethanol; water / 0.5 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;