1,6-Diazabicyclo[3.1.0]hexane-5-carboxylicacid,methylester,[1R-(1alpha,5alpha,6alpha)]-

Base Information

Chemical Name:1,6-Diazabicyclo[3.1.0]hexane-5-carboxylicacid,methylester,[1R-(1alpha,5alpha,6alpha)]-
CAS No.:111265-53-3
Molecular Formula:C₆H₁₀N₂O₂
Molecular Weight:142.158
Hs Code.:
Mol file:111265-53-3.mol

Synonyms:1,6-Diazabicyclo[3.1.0]hexane-5-carboxylicacid,methylester,[1R-(1alpha,5alpha,6alpha)]-

Suppliers and Price of 1,6-Diazabicyclo[3.1.0]hexane-5-carboxylicacid,methylester,[1R-(1alpha,5alpha,6alpha)]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,6-Diazabicyclo[3.1.0]hexane-5-carboxylicacid,methylester,[1R-(1alpha,5alpha,6alpha)]-

Chemical Property:

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Technology Process of 1,6-Diazabicyclo[3.1.0]hexane-5-carboxylicacid,methylester,[1R-(1alpha,5alpha,6alpha)]-

There total 1 articles about 1,6-Diazabicyclo[3.1.0]hexane-5-carboxylicacid,methylester,[1R-(1alpha,5alpha,6alpha)]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 57224-14-3
methyl-Δ¹-pyrroline-2-carboxylate

: 89019-22-7,111265-47-5,111265-50-0,111265-53-3
1,6-diazabicyclo<3.1.0>hexane-5-carboxylic acid methyl ester

Guidance literature:: With NCI-88947; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; hydroxylamine-O-sulfonic acid; In benzene; at 20 ℃; for 10h;
DOI:10.1007/BF00954608

Reference yield: 97.0%

: 89019-22-7,111265-47-5,111265-50-0,111265-53-3
1,6-diazabicyclo<3.1.0>hexane-5-carboxylic acid methyl ester

: 74-89-5
methylamine

: 89019-23-8,111265-51-1
5-N-Methylcarbomoyl-1,6-diazabicyclo<3.1.0>hexane

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 72h;
DOI:10.1007/BF00954608

Reference yield:

: 89019-22-7,111265-47-5,111265-50-0,111265-53-3
1,6-diazabicyclo<3.1.0>hexane-5-carboxylic acid methyl ester

: 89019-25-0,108392-48-9,108392-50-3,113085-29-3
endo-5-N-Methylcarbomoyl-6-chloro-1,6-diazabicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / MeONa / methanol / 20 °C

2: t-BuOCl / CH₂Cl₂ / -30 °C

With tert-butylhypochlorite; sodium methylate; In methanol; dichloromethane;
DOI:10.1039/c39830001275