2-Pyridinamine,N-(2-methylpropyl)-(9CI)

Base Information

• Chemical Name: 2-Pyridinamine,N-(2-methylpropyl)-(9CI)
• CAS No.: 111098-36-3
• Molecular Formula: C9H14 N2
• Molecular Weight: 150.22
• Mol file: 111098-36-3.mol

Synonyms:Pyridine,2-isobutylamino- (6CI); 2-(Isobutylamino)pyridine

Chemical Property of 2-Pyridinamine,N-(2-methylpropyl)-(9CI)

Chemical Property:

• Boiling Point: 96 °C (2 mmHg)
• PSA: 24.92000
• LogP: 2.22250

Purity/Quality:

N-(2-METHYLPROPYL)-2-PYRIDINAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinamine,N-(2-methylpropyl)-(9CI)

There total 7 articles about 2-Pyridinamine,N-(2-methylpropyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-chloropyridine (109-09-1) + isobutylamine (78-81-9) → N-iso-butyl-2-aminopyridine (111098-36-3)

Guidance literature:

With (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine; sodium t-butanolate; palladium diacetate; In 1,2-dimethoxyethane; at 70 ℃; for 15h;

DOI:10.1002/anie.200462629

Reference yield: 81.0%

2-<1-(benzotriazol-1-yl)-2-methylpropylamino>pyridine (111098-27-2) → N-iso-butyl-2-aminopyridine (111098-36-3)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; for 8h; Heating;

Reference yield: 68.0%

2-methyl-propan-1-ol (78-83-1) + 2-amino-5-fluoropyridine (21717-96-4) → N-iso-butyl-2-aminopyridine (111098-36-3)

Guidance literature:

With methanesulfonato(2-dicyclohexylphosphino -2’,6’-di-i-propoxy-1,1‘-biphenyl)(2’-amino-1,1’-biphenyl-2-yl)palladium(II); sodium tert-pentoxide; In toluene; at 80 ℃; for 2h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00889

upstream raw materials:

Isobutyl bromide

Natrium-Verbindung des [2]Pyridylamins

isobutyryl chloride

2-<1-(benzotriazol-1-yl)-2-methylpropylamino>pyridine

Downstream raw materials:

C₁₈H₁₈N₂O₂

Refernces

• 1、 Zhang, Wenming,Holyoke, Caleb W.,Barry, James,Leighty, Robert M.,Cordova, Daniel,Vincent, Daniel R.,Hughes, Kenneth A.,Tong, My-Hanh T.,McCann, Stephen F.,Xu, Ming,Briddell, Twyla A.,Pahutski, Thomas F.,Lahm, George P.. "Mesoionic pyrido[1,2-a]pyrimidinones: A novel class of insecticides inhibiting nicotinic acetylcholine receptors". . p. 5444 - 5449. Retrieved 2016/11/11.
• 2、 Katritzky, Alan R.,Rachwal, Stanislaw,Rachwal, Bogumila. "The Chemistry of N-Substituted Benzotriazoles. Part 4. A Novel and Versatile Method for the Mono-N-alkylation of Aromatic and Heteroaromatic Amines". . p. 805 - 810. Retrieved 2007/10/02.