3-{3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl}propanoic acid

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Chemical Name:3-{3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl}propanoic acid
CAS No.:1270038-08-8
Molecular Formula:C₂₉H₂₆F₆N₂O₆
Molecular Weight:612.526
Hs Code.:

Synonyms:3-{3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl}propanoic acid

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Chemical Property of 3-{3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl}propanoic acid

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Technology Process of 3-{3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl}propanoic acid

There total 14 articles about 3-{3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1270038-11-3
methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate

: 1270038-08-8
3-{3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl}propanoic acid

Guidance literature:: methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate; With water; lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 3h;

With acetic acid; In 1,4-dioxane;

Reference yield:

: 15823-04-8
methyl 3-(4-methoxyphenyl)propionate

: 1270038-08-8
3-{3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl}propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; silver sulfate / methanol / 1 h / 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; dimethyl sulfoxide / 17 h / 50 - 80 °C / Inert atmosphere

3: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4: water; lithium hydroxide / 1,4-dioxane / 3 h / 20 °C

With water; iodine; potassium acetate; potassium carbonate; silver sulfate; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;

Reference yield:

: 53937-17-0
methyl 3-(3-iodo-4-methoxyphenyl)propanoate

: 1270038-08-8
3-{3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl}propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; dimethyl sulfoxide / 17 h / 50 - 80 °C / Inert atmosphere

2: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3: water; lithium hydroxide / 1,4-dioxane / 3 h / 20 °C

With water; potassium acetate; potassium carbonate; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide;