3-(3-bromo-4-methoxyphenyl)-propionic acid methyl ester

Base Information

• Chemical Name: 3-(3-bromo-4-methoxyphenyl)-propionic acid methyl ester
• CAS No.: 288310-70-3
• Molecular Formula: C11H13BrO3
• Molecular Weight: 273.126
• Mol file: 288310-70-3.mol

Synonyms:3-(3-bromo-4-methoxyphenyl)-propionic acid methyl ester;methyl 3-(3-bromo-4-methoxyphenyl)propanoate

Chemical Property of 3-(3-bromo-4-methoxyphenyl)-propionic acid methyl ester

Chemical Property:

• PSA: 35.53000
• LogP: 2.56330

Purity/Quality:

>96% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-bromo-4-methoxyphenyl)-propionic acid methyl ester

There total 4 articles about 3-(3-bromo-4-methoxyphenyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 3-(4-methoxyphenyl)propionate (15823-04-8) → 3-(3-bromo-4-methoxyphenyl)-propionic acid methyl ester (288310-70-3)

Guidance literature:

With bromine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/j.bmcl.2011.11.025

Reference yield:

4-hydroxyphenylpropionic acid (501-97-3) → 3-(3-bromo-4-methoxyphenyl)-propionic acid methyl ester (288310-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: bromine; aluminum (III) chloride / dichloromethane / 0.33 h / 0 °C

With aluminum (III) chloride; bromine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

methanol (67-56-1) + 3-(3-bromo-4-methoxyphenyl)propionic acid (1857-57-4) → 3-(3-bromo-4-methoxyphenyl)-propionic acid methyl ester (288310-70-3)

Guidance literature:

With sulfuric acid; Heating;

DOI:10.1021/jf070014p

upstream raw materials:

methyl 3-(4-methoxyphenyl)propionate

methanol

3-(3-bromo-4-methoxyphenyl)propionic acid

4-hydroxyphenylpropionic acid

Downstream raw materials:

3-(3-bromo-4-methoxyphenyl)propionic acid

3-(3-bromo-4-methoxyphenyl)propanoyl chloride

methyl 4-(3-bromo-4-methoxy-phenyl)-2-oxo-butyrate

4-(3-bromo-4-methoxy-phenyl)-1,1,1-trifluoro-bytan-2-one