methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate

Base Information

Chemical Name:methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate
CAS No.:1270038-11-3
Molecular Formula:C₃₀H₂₈F₆N₂O₆
Molecular Weight:626.553
Hs Code.:

methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate

Synonyms:methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate

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Chemical Property of methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate

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Technology Process of methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate

There total 13 articles about methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1270038-09-9
methyl 3-[4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoate

: 1270038-10-2
(4S,5R)-5-[3-5-bis(trifluoromethyl)phenyl]-3-[(3-bromo-6-methoxypyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one

: 1270038-11-3
methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate

Guidance literature:: With potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; water; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 875444-08-9
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

: 1270038-13-5
C₁₈H₂₀ClNO₄

: 1270038-11-3
methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate

Guidance literature:: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one; With sodium hexamethyldisilazane; In N,N-dimethyl-formamide; at -20 - -15 ℃;

C₁₈H₂₀ClNO₄; In N,N-dimethyl-formamide; at -15 - 20 ℃;

Reference yield:

: 53937-17-0
methyl 3-(3-iodo-4-methoxyphenyl)propanoate

: 1270038-11-3
methyl 3-(3-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-6-methoxypyridin-3-yl]-4-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; dimethyl sulfoxide / 17 h / 50 - 80 °C / Inert atmosphere

2: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With potassium acetate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide;