methyl (R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanoate

Base Information

• Chemical Name: methyl (R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanoate
• CAS No.: 932739-31-6
• Molecular Formula: C₁₅H₂₀O₄
• Molecular Weight: 264.321
• Mol file: 932739-31-6.mol

Synonyms:methyl (R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanoate

Chemical Property of methyl (R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanoate

There total 2 articles about methyl (R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(3R,4R,5R)-4-hydroxy-3-methyl-5-phenyl-tetrahydrofuran-2-one (932739-30-5) + 2,2-dimethoxy-propane (77-76-9) → methyl (R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanoate (932739-31-6)

Guidance literature:

With amberlyst-15(R); In methanol; at 20 ℃; for 96h;

DOI:10.1021/ol063032l

Reference yield: 88.0%

(3R,4R,5R)-4-hydroxy-3-methyl-5-phenyl-tetrahydrofuran-2-one (932739-30-5) + methanol (67-56-1) + 2,2-dimethoxy-propane (77-76-9) → methyl (R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanoate (932739-31-6)

Guidance literature:

With Amberlyst-15; at 20 ℃; for 96h; Inert atmosphere;

DOI:10.1002/chem.200901750

Reference yield: 100.0%

methyl (R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanoate (932739-31-6) → (R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanal (932739-32-7)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 4h;

DOI:10.1021/ol063032l

upstream raw materials:

(3R,4R,5R)-4-hydroxy-3-methyl-5-phenyl-tetrahydrofuran-2-one

2,2-dimethoxy-propane

methanol

Downstream raw materials:

(R)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]propanal

(5S,6S,2E)-tert-butyl 6-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-5-hydroxyhept-2-enoate

(2S,3S)-2-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]hex-5-en-3-ol