4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-D-phenylglycinotrile

Base Information

• Chemical Name: 4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-D-phenylglycinotrile
• CAS No.: 108365-45-3
• Molecular Formula: C₃₄H₄₉FN₂O₉
• Molecular Weight: 648.769

Synonyms:4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-D-phenylglycinotrile

Chemical Property of 4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-D-phenylglycinotrile

Chemical Property:

Purity/Quality:

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Technology Process of 4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-D-phenylglycinotrile

There total 18 articles about 4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-D-phenylglycinotrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

trimethylsilyl cyanide (7677-24-9) + 2-nitro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)benzylideneamine (135968-95-5) → 4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-α-D-galactopyranosyl)-D-phenylglycinotrile (108365-45-3,120255-36-9)

Guidance literature:

With tin(IV) chloride; In tetrahydrofuran; at -18 ℃; for 8h;

Reference yield: 84.0%

trimethylsilyl cyanide (7677-24-9) + 4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)benzylideneamine (121841-86-9) → 4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-D-phenylglycinotrile (108365-45-3)

Guidance literature:

With tin(IV) chloride; In tetrahydrofuran; at -18 ℃; for 8h;

Reference yield: 84.0%

trimethylsilyl cyanide (7677-24-9) + 4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)benzylideneamine (121841-86-9) → 4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-D-phenylglycinotrile (108365-45-3) + 2,2-Dimethyl-propionic acid (2R,3R,4S,5S,6R)-2-{[(S)-cyano-(4-fluoro-phenyl)-methyl]-amino}-3,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-4-yl ester (120255-36-9)

Guidance literature:

With tin(IV) chloride; In tetrahydrofuran; at -78 - -30 ℃; for 8h; Yields of byproduct given;

upstream raw materials:

hydrogen cyanide

4-fluoro-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)benzylideneamine

trimethylsilyl cyanide

4-fluorobenzaldehyde

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