N-{4-[5-(acetylamino)-1H-pyrrolo[3,2-b]pyridin-2-yl]phenyl}-1-(phenylacetyl)-L-prolinamide

Base Information

Chemical Name:N-{4-[5-(acetylamino)-1H-pyrrolo[3,2-b]pyridin-2-yl]phenyl}-1-(phenylacetyl)-L-prolinamide
CAS No.:1246468-33-6
Molecular Formula:C₂₈H₂₇N₅O₃
Molecular Weight:481.554
Hs Code.:

Synonyms:N-{4-[5-(acetylamino)-1H-pyrrolo[3,2-b]pyridin-2-yl]phenyl}-1-(phenylacetyl)-L-prolinamide

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Chemical Property of N-{4-[5-(acetylamino)-1H-pyrrolo[3,2-b]pyridin-2-yl]phenyl}-1-(phenylacetyl)-L-prolinamide

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Technology Process of N-{4-[5-(acetylamino)-1H-pyrrolo[3,2-b]pyridin-2-yl]phenyl}-1-(phenylacetyl)-L-prolinamide

There total 7 articles about N-{4-[5-(acetylamino)-1H-pyrrolo[3,2-b]pyridin-2-yl]phenyl}-1-(phenylacetyl)-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29958-14-3
N-(5-aminopyridin-2-yl)acetamide

: 1246468-33-6
N-{4-[5-(acetylamino)-1H-pyrrolo[3,2-b]pyridin-2-yl]phenyl}-1-(phenylacetyl)-L-prolinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.75 h / 0 °C

1.2: 16 h / 0 - 20 °C

2.1: triethylamine / ethanol / 3 h / pH 9.5 / Reflux

3.1: polyphosphoric acid / 1.25 h / 90 °C / Inert atmosphere

4.1: hydrogenchloride; water / 2 h / Reflux

5.1: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

6.1: triethylamine / acetonitrile / 0.6 h / 0 - 25 °C

With hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium nitrite; In ethanol; water; acetonitrile;

Reference yield:

: 1246470-73-4
C₂₆H₂₅N₅O₂

: 75-36-5
acetyl chloride

: 1246468-33-6
N-{4-[5-(acetylamino)-1H-pyrrolo[3,2-b]pyridin-2-yl]phenyl}-1-(phenylacetyl)-L-prolinamide

Guidance literature:: With triethylamine; In acetonitrile; at 0 - 20 ℃;

Reference yield:

: 4214-76-0,67476-67-9
5-nitro-pyridin-2-ylamine

: 1246468-33-6
N-{4-[5-(acetylamino)-1H-pyrrolo[3,2-b]pyridin-2-yl]phenyl}-1-(phenylacetyl)-L-prolinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine; dmap / 5 h / 0 - 25 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 2585.81 Torr

3.1: sodium nitrite; hydrogenchloride / water / 0.75 h / 0 °C

3.2: 16 h / 0 - 20 °C

4.1: triethylamine / ethanol / 3 h / pH 9.5 / Reflux

5.1: polyphosphoric acid / 1.25 h / 90 °C / Inert atmosphere

6.1: hydrogenchloride; water / 2 h / Reflux

7.1: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

8.1: triethylamine / acetonitrile / 0.6 h / 0 - 25 °C

With pyridine; hydrogenchloride; dmap; palladium 10% on activated carbon; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium nitrite; In methanol; ethanol; water; acetonitrile;